摘要
目的 :探讨急性脑梗死 (ACI)患者的血浆神经肽 ;β -内啡肽 (β -EP)、神经降压素 (NT)、神经肽Y(NPY)水平变化及纳洛酮疗效。方法 :(1)采用放射免疫分析 (RIA)检测ACI组 38例发病后第 1、3、7、14天上述血浆神经肽含量变化并与健康人组比较 ;(2 )把ACI随机分成纳洛酮组 18例与血栓通组 2 0例比较血浆神经肽变化及纳洛酮疗效。结果 :(1)ACI组血浆β -EP、NT、NPY含量显著高于健康人组 (分别为F =4 6 6 6 ,p =0 0 0 <0 0 1;F =6 0 31,p =0 0 0 0 <0 0 1;F =2 9 6 75 ,p =0 0 0 0 <0 0 1)。发病时含量最高 ,至第 14天接近健康组水平 ;(2 )纳洛酮组第 3、7天β -EP水平显著低于血栓通组 (分别为t=- 2 13,p <0 0 5 ;t =- 3 0 6 ,p <0 0 1) ,两组的NT、NPY无差异 ;纳洛酮组总有效率优于血栓通组。 结论 :神经肽 β -EP、NT、NPY直接参与了急性脑梗死的病理生理变化 ,对ACI治疗观察有重要临床意义 ;纳洛酮能有效拮抗β -EP ,减轻脑水肿 ,促进急性脑梗死康复。
Objective To inveshgate the changs of plasma neuropetides (β-EP.NT.NPY) levels in patients with acute cerebral infarction and the clinical efficacy of Naloxone. Methods (1) The concentraion of these neuropetides were measured on the 1st, 3rd, 7th, 14th day after the onset of disease with RIA in 38 patients with acute cerebral infaction and 66 controls. (2) 38 cases of acute cerebral infacrction were randomly divided into treatment groups. Naloxone and Xue shuan tong. The concentraion of these neuropetides in the two groups were compared with each other and clinical efficacy of Naloxone was observed. Results (1)Plasma β-EP. NT and NPY levels in the patients with acute cerebral infarction were significantly higher than those in control ( F=46 66,p=0 00<0 01;F=6 031,p=0 000<0 01;F=29 675,p<0 01 ). The levels were highest at the onset and approaching normal on the 14th day. (2)The plasma β-EP levels at 3rd and 7th days in the Naloxone group were significantly high than those in the xue Shuan tong group ( p<0 05,p<0 01 respectively ). For NT and NPY levels, there were no significant differences. Clinical result of treatment was much better with Naloxone were obvious than group. Conclusion The plasma neuropetide levels (β-EP.NT.NPY) were closely related to the pathogenesis of acute cerebral infarction and might be very useful in the clinical treatment of the diseases. Naloxone could effectly resist β-EP and reduce hydrocehelus and improve the convalescence of acute cerebral infarction.
出处
《放射免疫学杂志》
CAS
2003年第5期272-275,共4页
Journal of Radioimmanology
基金
2000年7月珠海市科技局立项资助课题
