摘要
目的 :探讨急性心、脑血管疾病的发病、转归与血浆神经肽 :神经肽Y(NPY)、神经降压肽 (NT)、β-内啡肽 (β -EP)含量变化关系。方法 :采用放射免疫分析法 (RIA)分别检测 10 3例 (急性脑梗塞 38例、急性脑出血 32例、急性心肌梗塞及各种急性心衰 33例 )疾病发病后第 1、3、7、14天血浆 3种神经肽含量 ,并设相应对照组。结果 :(1)急性心、脑血管疾病的血浆 β-EP、NPY、NT含量显著升高 (与对照组比较分别为F =39 5 4 ,p=0 0 0 <0 0 1;F =33 38,p=0 0 0 <0 0 1;F =8 38,p =0 0 0 <0 0 1)。 (2 )发病时血浆神经肽水平最高 ,3天以后降低 ,至第 14天接近正常。结论 :血浆神经肽与急性心、脑血管疾病的发病、转归关系密切 ,直接参与急性心脑血管疾病的病理生理过程 ,对疾病的观察、治疗具有重要意义。
Objective To explore the relationship between the dynamic changes of plasma neuropeptide (β-EP, NT, NPY) levels and the pathogenesis as well as clinical outcomes of acute cardiovascular and cerebrovascular diseases. Methods The concentrations of serum neuropeprtides (β-EP,NT,NPY) were measured on the 1 st, 3 rd, 7 th, 14th day after the onset of disease with RIA in 103 patients with acute cardiovascular and cerebrovascular diseases (38 cases of acute cerebral infarctoin, 32 cases of cerebral hemorrhage, 33 cases of acute myocardial infarction and acute heart failure) and 66 controls. Results 1. NPY,NT and β-EP levels in patients with acute cardiovascular and cerebrovascular diseases were significantly higher than those in controls ( p <0 01). (F=39 54, p <0 01;F=33 38, p <0 01;F=8 38, p <0 01 For β-EP,NPY and NT respectively). 2. The plasma neuropeptide levels were highest at onset and gradually lowered olse to normal levels on the 14 th day. Conclusion Plasma neuropeptide levels were closely related to the pathogenesis and clinical outcome of acute cardiovascular and cerebrovascular diseases, study of which might be useful in the clinical management of the diseases.
出处
《放射免疫学杂志》
CAS
2003年第3期129-131,共3页
Journal of Radioimmanology
基金
2000年7月珠海市科委立项的科研项目,编号:39
