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血管紧张素-(1-7)对心肌细胞L-型钙通道的影响 被引量：2

Effect of angiotensin-(1-7)on L-type calcium channel in guinea pig myocytes
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摘要 目的 :研究血管紧张素 (1 7) [Ang (1 7) ]对正常豚鼠心室肌细胞L 型钙离子通道的影响 ,旨在探讨Ang (1 7)发挥降压作用的离子通道及分子基础。 方法 :应用膜片钳全细胞记录技术。结果 :Ang (1 7)可使ICa L呈浓度依赖性增加 ,选择性AngⅠ型 (AT1)受体拮抗剂缬沙坦或非选择性AT1受体拮抗剂Sarthran(Sar)均可消除Ang (1 7)增加ICa L的作用。结论 :Ang (1 7)通过AT1受体增加ICa L,其降压作用不是通过抑制钙离子内流而实现的。 Objective:To investigate the mechanism of hypotensive effects of angiotensin(Ang)-(1-7) in guinea pig.Methods:Membrane currents were recorded with patch electrodes in a whole-cell clamp configuration.Results:The present results showed that: I Ca-L was increased by Ang-(1-7) in a concentration dependent manner. The effects of Ang-(1-7) on I Ca-L can be eliminated by specific AT 1 antagonist Valsartan and non-specific AT antagonist Sarthran.Conclusion:These results suggest that: Ang-(1-7) increase the amplitude of I Ca-L through AT 1 receptor. The hypotensive effects of Ang-(1-7) have no relationship with inward calcium current increase.
作者 李晓东 尹德录 叶琳 蒋文平
机构地区 山东省立医院保健科 连云港市人民医院心内科 苏州大学附属第一医院心内科
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2003年第11期674-676,共3页 Journal of Clinical Cardiology
关键词 血管紧张素 心肌 钙离子通道 电生理学 Angiotensin Myocardium Calcium channels Electrophysiology
分类号 R972 [医药卫生—药品]
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参考文献5

  • 1Brosnihan K B, Li P, Ferrario C M. Angiotensin-(1-7)dilates canine coronary arteries through kinin and nitric oxide. Hypertension, 1996,27:523-- 528.
  • 2Sun H, Leblanc N, Nattel S. Mechanisms of inactivation of L-type calcium channels in human artrial myocytes. Am J Physiol, 1997,273:H1625--H1635.
  • 3Nussberger J. Ang I and Ang II disappear completely from circulation blood within 48 hours after binephrectomy:improved measurement of angiotensin in rat plasma. J Hypertens, 1991,9:S230--S231.
  • 4Paula R D, Lima C V, Khosla M C, et al. Angiotensin-(1-7) potentiates the hypotensive effect of bradykinin in conscious rats. Hypertension, 1995,26 : 1154-- 1159.
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同被引文献17

  • 1YANG X, JIANG W. Angiotensin Ⅱ receptor regulates ionic currents in guinea pig ventricular myocytes [J]. J Cardiovasc Pharmacol Therapeut, 1998, 3 : 1- 10.
  • 2KAJIMARA K, YANGITA T, NAKASHIMA Y, et al. Differential effects of short and prolonged exposure to carvedilol on voltage-dependent Na^+ channels in cultured bovine adrenal medullary cells [J]. J Phmarcol Exp Ther, 2002,302:212-218.
  • 3PODRID P J, FUCHS T, CANDINAS R. Role of the sympathetic nervous system in the genesis of ventricular arrhythmia[J]. Circulation, 1990, 82 (Suppl Ⅰ):I103-I113.
  • 4LOUIS A, CLELAND JGF, CRABBE S, et al. Clinical trials update: CAPRICORN, COPERNICUS, MIRACLE, STAF, RITZ-2, RECOVER and RENAISSANCE and cachexia and cholesterol in heart failure, highlights of the scientific sessions of the American College of Cardiology, 2001[J].Eur J Heart Fail, 2001, 3: 381-387.
  • 5SENIOR R, MULLER-BECKMANN B, DASGUPTA P, et al. Effects of carvedilol on ventricular arrhythmias[J]. J Cardiovasc Pharmacol, 1992, 19:S117-S121.
  • 6CICE G, TAGLIAMONTE E, FERRARA L, et al. Complex ventricular arrhythmias and carvedilol: Efficacy in hemodialyzed uremic patients[J].Cardiologia, 1998, 43:597-604.
  • 7Konstantinos P. Letsas,Reinhold Weber,Klaus Astheimer.T-peak-T-end interval and T-peak-T-end/QT ratio as markers of ventricular tachycardia inducibility in subjects with Brugada ECG phenotype[].Europace.2010
  • 8Piepoli M F,Capucci A.Autonomic nervous system in the genesis of arrhythmias in chronic heart failure: implication for risk stratification[].Minerva cardioangiologica.2007
  • 9S.G. Priori,E. Aliot,C. Blomstrom-Lundqvist,L. Bossaert,G. Breithardt,P. Brugada,A.J. Camm,R. Cappato,S.M. Cobbe,C. Di Mario,B.J. Maron,W.J. McKenna,A.K. Pedersen,U. Ravens,P.J. Schwartz,M. Trusz-Gluza,P. Vardas,H.J.J. We.Task Force on Sudden Cardiac Death of the European Society of Cardiology[].European Heart Journal.2001
  • 10WE Cascio.Myocardial ischemia: what factors determine arrhythmogenesis?[].Journal of Cardiology.2001

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临床心血管病杂志
2003年 第11期

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