摘要
目的 :探讨 CD55、CD59对阵发性睡眠性血红蛋白尿症 (PNH)的临床诊断意义。方法 :应用流式细胞仪 (FCM)检测人体外周血红细胞、粒细胞、淋巴细胞的表面抗原 CD55、CD59的表达水平。结果 :PNH患者 CD55、CD59表面抗原在红细胞、粒细胞、淋巴细胞上均有不同程度的缺乏 ,尤以红细胞、粒细胞较明显。再生障碍性贫血患者的红细胞、粒细胞、淋巴细胞 CD55、CD59表面抗原标记阳性率与正常对照组比较差异无显著性 (P>0 .0 5)。结论 :流式细胞仪检测 PNH患者外周血红细胞、粒细胞、淋巴细胞 CD55、CD59表面抗原具有重要的临床诊断意义。
Objective:To investigate the significance of clinical diagnosis of paroxysmal nocturnal hemoglobinuria(PNH) with CD55 and CD59.Methods:Flow cytometry was used to detect the expression of CD 55 and CD 59 in peripheral blood cells (red blood cells,granulocytes and lymphocytes).Results:CD55 and CD59 antigen expression were to vary degrees deficiency on the red blood cells,granulocytes and lymphocytes in patients with PNH,especially more remarkable of red blood cells and granulocytes.Aplastic anemia(AA) were not significantly different from the normal controls ( P > 0.05 ).Conclusion: There is important clinical significance for diagnosis of PNH patients in the determination of CD55 and CD59 expression on the red blood cells,granulocytes and lymphocytes.
出处
《广东医学院学报》
2001年第6期411-412,共2页
Journal of Guangdong Medical College
