摘要
[目的]探讨细胞外信号调节激酶(ERK)在卵巢上皮性肿瘤组织中的表达及其意义.[方法]应用免疫组织化学技术,检测49例卵巢上皮性癌组织、26例卵巢上皮性良性肿瘤组织及10例正常卵巢组织中ERK1/2蛋白和活性ERK1/2蛋白表达.[结果]ERK1/2在卵巢上皮性癌组织中的表达阳性率为63%,显著高于正常卵巢组织(阴性)和卵巢良性肿瘤组织(27%)(P＜0.01).活性ERK1/2在卵巢上皮性癌中的阳性表达率为65%,明显高于卵巢良性肿瘤组织中的阳性表达率19%(P＜0.01).Ⅲ～Ⅳ期卵巢癌组织中ERK1/2及活性ERK1/2表达水平高于Ⅰ～Ⅱ期,差异有显著性(P＜0.05,P＜0.01).病情进展患者活性ERK1/2表达阳性率为82%,较病情未进展者(43%),差异有显著性(P＜0.01).[结论]ERK蛋白的过表达在卵巢上皮性癌患者的发生、发展中可能起重要促进作用,可判断卵巢上皮性癌的病情进展情况.
[Purpose]To investigate the expression of extracellular signal-regulated kinase(ERK)and its sig-nificance in epithelial ovarian tumor.Expression of ERK1/2protein and active ERK1/2were ex-amined by immunohistochemical method in49patients with epithelial ovarian cancer,26patients with be-nign epithelial ovarian tumor and10normal ovarian tissues.The positive percentage of ERK1/2protein in ovarian cancer was63%,which was significantly higher than that in benign tumors and normal o-varian tissues(P<0.01).The positive percentage of active ERK1/2in ovarian cancer(65%)was significantly higher than that in benign tumors(19%).The positive percentages of ERK1/2protein and active ERK1/2in stageⅢ~Ⅳepithelial ovarian cancer was significantly higher than those in stageⅠ~Ⅱepithelial ovarian cancer(P<0.05,P<0.01)respectively.The positive percentage of active ERK1/2in progressive patients with epithelial ovarian cancer(82%)was significantly higher than that in patients in remission(43%,P<0.01).[Conclusions]The overexpression of ERK may play an important role in the initiation and development of human ovarian cancer,and judge the progression of epithelial ovarian cancer.
出处
《中国肿瘤》
CAS
2003年第11期682-684,共3页
China Cancer
关键词
卵巢肿瘤
细胞外信号调节激酶
免疫组织化学
ovarian neoplasms
extracellular signal-regulated kinase
immunohistochemistry
