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磷酸化ERK1/2在非小细胞肺癌中的表达及意义 被引量：1

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摘要 目的:探讨磷酸化ERK 1/2在非小细胞肺癌发生、发展中的作用及其与K i-67表达的相互关系。方法:应用免疫组织化学技术检测10例正常肺组织和64例非小细胞肺癌组织中P-ERK、K i-67的表达情况。结果:肺癌组织中P-ERK的总阳性率和细胞核的阳性率分别为57.8%、45.3%,正常肺组织全为阴性。P-ERK与TNM分期、淋巴结转移有关(P<0.05);P-ERK与K i-67在肺癌中的表达无相关性(P>0.05)。结论:ERK 1/2介导的信号转导通路可能在非小细胞肺癌发生、发展过程中起重要促进作用。
作者 蒋宇 朱润庆
机构地区 武汉大学中南医院 武汉大学医学院病理学教研室
出处 《数理医药学杂志》 2006年第1期28-29,共2页 Journal of Mathematical Medicine
关键词 非小细胞肺癌 细胞外信号调节激酶 磷酸化
分类号 R734.2 [医药卫生—肿瘤]
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参考文献7

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数理医药学杂志
2006年 第1期

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