摘要
目的 :了解我院产超广谱β-内酰胺酶菌株的分布和耐药情况。方法 :用 Kirby- Bauer法检测了136株产超广谱 β-内酰胺酶的大肠埃希菌和肺炎克雷伯菌对 10种抗生素耐药性并对其标本来源和病区分布进行了分析。结果 :检出 ESBL s最多的标本是呼吸道分泌物 (43.4 % ) ,检出 ESBL s最多的科室是普外科(2 2 .8% )。 136株产 ESBL s菌株对亚胺培南和美洛培南的敏感率高达 10 0 % ,对多数抗生素的敏感率低于5 0 %。结论 :呼吸道分泌物和普外科是 ESBL s的主要来源。治疗产 ESBL s菌株引起的感染的首选药物为亚胺培南和美洛培南。产 ESBL s肺炎克雷伯菌对药物的敏感性普遍低于产 ESBL s大肠埃希菌。
Objective: To investigate the antibiotic-resistance and distribtion of clinical isolates that produce extended-spectrum β-lactamase(ESBLs) in our hospital .Methods:Antibiotic susceptibilities of 136 ESBLs-prodcing strains of E.coli and K.pneumoniae were determined by Kirby-Bauer test.Results:43.4% of all ESBLs strains were isolated from Respiratory tract secretions . UP to 22.8% ESBLs strains come from general surgery department.All of 136 ESBLs-prodcing strains were susceptible to imipenem and Meropenem ,but to the other antibiotics the susceptible rates are mostly below 50%.Conclusion:The important sources of ESBLs were respiratory tract secretions or general surgery department.Imipenem and Meropenem are the best drug for treatment of infection with ESBLs producing strain, . The antibiotic susceptibility of K.pneumoniae are lower than E.coli mostly.
出处
《中国微生态学杂志》
CAS
CSCD
2003年第5期285-286,共2页
Chinese Journal of Microecology
