摘要
目的:探讨脑卒中患者早期血清C反应蛋白(C-reactiveprotein,CRP)含量与脑卒中后抑郁的关系,并分析其意义。方法:选择住院确诊为脑卒中的患者,共98例,男53例,女45例,年龄42～79岁,平均56.7岁,其中脑梗死49例,脑出血42例,蛛网膜下腔出血7例,病程3～40h。应用TurboxR特定蛋白分析系统(芬兰)以散射比浊法测定血清CRP含量;并采用十七项版本的汉密尔顿(HAMD)抑郁量表,分别于入院后2,3,4周进行评定。并按照患者评分情况分入无抑郁症组(3次评分均≤17分)、轻度抑郁症组(任何一次24>评分>17分)、重度抑郁症组(任何一次评分≥24分者)。并选取同期正常健康人50例作为对照。结果:正常对照组所有患者HAMD评分均在17分以下,其血清CRP含量处于较低水平。脑卒中组急性期抑郁障碍发病率为51%(50/98),但无抑郁症组患者其HAMD评分较正常对照组明显增高(t=2.055,P=0.043)。脑卒中各组患者血清CRP水平均明显增高,无抑郁症组(6.51±3.44)mg/L、轻抑郁症组(14.66±4.14)mg/L及重抑郁症组(19.35±4.52)mg/L与正常对照组(6.51±3.44)mg/L相比,差异均有显著意义(分别t=3.025,P=0.026;t=11.260,P=0.000;t=16.432,P=0.000)。随抑郁症严重程度的增加,HAMD评分逐渐增高,血清CRP含量增高程度更明显,轻抑郁症组及重抑郁症组与无抑郁症组?
AIM:To reveal the relationship between s erum level of C-reactive protein(CRP)in acute phase of stroke and the post-stroke depression and to analyze the significance.METHODS:Ninety-eight inpatients diagnosed as stroke within 3-40h,53males and 45females,who were averagely 56.7years of age,included49cases of cerebral infarction,42o f cerebral hemorrhage and 7of sub-arachnoid hemorrhage.Hamilton dep ression scale(HAMD)was used to de-termine their status of depression a t 2,3and 4weeks after admission re-spectively.They were divided into n on-depression group(score at all 3times<17),mild depression group(24>score at least one time>17)and severe depression group(score≥24)according to their depression score.CRP levels were measured by scatter turbidimet ry with TurboxR special protein analysis system(Finland)in all patients after admission.Fifty normal subjects were chosed as controls.RESULTS:All the depression scores of normal s ubjects according to HAMD depression scale were under 17and th eir serum CRP concentrations were in a basic level.The acute incidence rat e of post-stroke depression in strok e pa-tients was 51%(50/98).The average score of HAMD in stroke p atients without depression was significant ly higher than that of the normal subj ects(t=2.055,P=0.043).The levels of serum CRP in all groups of stroke patients were(6.51±3.44)mg /L for the non-depression group,(14.66±4.14)mg /L for the mild depression group an d(19.35±4.52)mg /L for the severe group,significantly hig her than(6.51±3.44)mg /L for the control group(t=3.025,P=0.026;t=11.260,P=0.000;t=16.432,P=0.000respectively).Following the increase of depression score of pa-tients with stroke,the levels of serum CRP concentration was increased correspondingly and significant di fference was showed among the three s troke groups(t=2.12,P=0.040;t=7.221,P=0.000;t=5.010,P=0.006).
出处
《中国临床康复》
CSCD
2003年第28期3838-3839,共2页
Chinese Journal of Clinical Rehabilitation
关键词
脑卒中
血清
C反应蛋白
抑郁症
脑出血
ON:Serum CRP concentration can regard a s a prognostic im-plications of post-stroke depression in patients with acute stroke.
