摘要
目的 :研究抑肽酶对心脏直视手术患者体液免疫系统及补体的影响。方法 :将 6 0例心脏直视手术患者 ,分成用抑肽酶组与对照组。测定患者手术前、手术当天及手术后 1～ 3天血浆免疫球蛋白 (Ig)及补体含量 ,进行对比研究。结果 :用抑肽酶组和对照组 ,术后当天患者血液中的Ig及补体均明显下降 (P<0 0 0 1) ,从术后第 1天开始升高 ,在术后第 3天 ,抑肽酶组IgG、IgA及补体C3、C4、CH5 0均恢复正常 (P >0 0 5 ) ,而IgM、IgE和对照组Ig及补体尚未恢复至术前水平。结论 :抑肽酶在心脏直视手术期间对患者的免疫系统及补体无明显的保护作用 ,但对患者手术后的免疫系统及补体的恢复有促进作用。
Objective:Study of aprotinin effect on patients immunity system and complement during open heart operation.Methods:Ig and complement in patients' blood were measured respectively before operation and on the operative day and the first,second,third postoperative day.Results:In both aprotinin and comparative groups,the plasma levels of IgG,IgA,IgM,IgE and complement C3,C4,CH50 dropped remarkably and began to rise from the first postoperative day.On the third postoperative day, the plasma levels of IgG,IgA and complement C3,CH50 basically restored to the levels before operation.While IgM,IgE and complement C4 in aprotinin group and all Ig with complement in comparative group did not.Conclusion:Aprotinin has not a protective function to patients' immnunity system and complement during open heart operation but it can improve their restoration postoperatively.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2003年第10期716-717,721,共3页
Chinese Journal of Immunology
关键词
抑肽酶
免疫
补体
心脏直视手术
Aprotinin
Immunity
Complement
Open heart operation
