摘要
为观察体外循环对病人特异性体液免疫功能的影响,通过对30例行体外循环心脏瓣膜替换术患者手术前后外周血免疫球蛋白(IgG、IgA、IgM)含量,T辅助、B淋巴细胞数目,淋巴细胞体外培养诱生IgG、IL-2、IL-4能力的变化进行动态观察。结果发现,术后早期上述各项指标均有不同程度降低,2周内均恢复至术前水平。结果表明,体外循环术后机体特异性体液免疫功能低下。表现为IgG持续低下为主的体液免疫功能状态低下和B淋巴细胞数目减少、IgG诱生能力及T_H细胞抗体生成辅助能力减弱的体液免疫应答能力低下,是术后抗感染能力低下的原因,并强调围手术期采用保护和增强病人免疫功能,强化预防感染措施的重要。
To determin the effect of cardiopulmonary bypass (CPB) on specific humoral immune function in 30 patients with rheumatic heart disease receiving valve replacement. Serum IgG, IgA, IgM, T-helper and Blymphocyte counts, production of IgG, interleukin-2 (IL-2), interleukin-4 (IL-4) of peripheral blood mononuclear cells were stud- ied on the day 1, 3, 7 before operation, and 14th days after operation. The results showed that all these parameters decreased significantly on the early postoperative days as compared with preoperative values and returned to preoperative levels within 7 to 14 days. Our results suggested that specific humoral immune function was depressed for at least one week following CPB. It was demonstrated that effective measures should be taken to offer sufficient to protect the humoral immune function and reduce infection.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1997年第1期28-29,共2页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金
关键词
体外循环
心脏瓣膜替换
体液免疫
cardiopulmonary bypass cardiac valve replacement humoral immunity interleukin-2 interleukin-4
