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凝血因子ⅩⅢ Val34Leu多态性与心脑血管疾病 被引量：3

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摘要 凝血因子(F)是凝血途径最后一步的关键酶,在正常凝血过程中起着交联纤维蛋白的重要作用。近年的研究发现,位于Fa亚单位2号外显子上的34号密码子G→T突变,导致其所编码的缬氨酸转变为亮氨酸,即VaB4Leu多态性,与心脑血管疾病有明确的相关性。Leu34对防止脑梗死、心肌梗死的发生是一种保护因素,而对出血性卒中则可能是一种危险因素。
作者 张玉蓉 李正仪
机构地区 西安交通大学第一医院神经内科
出处 《国外医学（脑血管疾病分册）》 2003年第5期384-386,共3页 Foreign Medical Sciences Cerebrovascular Diseases
关键词 凝血因子ⅩⅢ VAL34LEU 多态性 心脑血管疾病 脑梗死 脑出血 基因
分类号 R743.3 [医药卫生—神经病学与精神病学] R54 [医药卫生—心血管疾病]
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参考文献18

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二级参考文献9

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共引文献8

同被引文献23

  • 1杜贻萌,路方红,王克志,吴凡,田奇,孙慧,商清.凝血因子Ⅶ及其基因MspI多态性与高血压合并脑梗死的相关性[J].中国动脉硬化杂志,2004,12(6):691-694. 被引量：5
  • 2黄赛玉,谭利明,肖志杰,蒋波,吴军,卢伟.载脂蛋白E基因多态性与不同性别老年脑出血患者的关系[J].中华老年心脑血管病杂志,2006,8(4):252-254. 被引量：3
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  • 10Mrozikiewicz PM,Cascorbi I,Ziemer S,Laule M,Meisel C,Stangl V,et al.Reduced procedural risk for coronary catheter interventions in carriers of the coagulation factor-GIn353 gene[J].J Am Coll Cardiol, 2000,36(5):1520-525.

引证文献3

国外医学（脑血管疾病分册）
2003年 第5期

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