摘要
目的 探讨凝血因子 XⅢ (FXⅢ )基因 Va134Leu突变与中国人群脑出血发病的相关关系。方法 利用等位基因特异性聚合酶链反应技术分析了 150例原发性脑出血病人和 150例非脑卒中对照组 FXⅢ基因的基因型位点频率。结果 在所研究的人群中发现了 4例 FXⅢ基因 Val34Leu突变的杂合子，全部位于脑出血组，没有发现突变型的纯合子。等位基因 Val34和 Leu34在所研究的中国人群中的频率分别是 99.3％和 0.7％。结论 FXⅢ基因 Val34Leu突变可能与中国人群的脑出血有潜在的关系。
Objective To investigate whether coagulation factor XⅢ (FXⅢ ) gene Val34Leu mutation is associated with cerebral hemorrhage.Method The genotype of FXⅢ gene was analyzed in 150 patients with primary cerebral hemorrhage pationts and 150 controls without cerebral vascular disease with allele specific polymerase chain reaction.Result In this study,there are 4 FXⅢ gene Val34Leu mutation heterozygotes and all in cerebral hemorrhage group.The allele frequency of Val34 and Leu34 is 99.3％ and 0.7％ respectively in the group.Conclusion These results suggested that FXⅢ gene Val34Leu mutation might have some relationship with cerebral hemorrhage.
出处
《现代康复》
CSCD
2001年第2期92-93,共2页
Modern Rehabilitation
