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凝血因子XⅢ与脑出血及继续出血

Association of intracerebraI hemorrhage and hematoma enlargement with FXⅢ
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摘要 脑出血是指原发性脑实质出血，它是神经科的常见病和多发病，占全部脑卒中的10％～15％，是脑卒中死亡率、致残率最高的一种类型。以往认为脑出血的出血时间极短，一般于人院时出血已经停止，而临床症状的恶化多为脑水肿和并发症所致。近年来，随着CT等影像技术的普及，越来越多的研究证实脑出血继续出血引起的血肿增大是导致神经功能缺失的重要因素。
作者 李刚 褚晓凡
机构地区 暨南大学第二临床学院神经内科
出处 《中华神经医学杂志》 CAS CSCD 2008年第4期425-427,共3页 Chinese Journal of Neuromedicine
关键词 凝血因子XⅢ 脑出血 FXⅢ Cerebral hemorrhage
分类号 R743.34 [医药卫生—神经病学与精神病学]
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参考文献18

  • 1Qureshi AI, Tuhrim S, Broderick JP, et al. Spontaneous intracerebral hemorrhage[J]. N Engl J Med, 2001,344(19): 1450-1460.
  • 2Dennis MS. Outcome after brain hemorrhage[J]. Cerebrovasc Dis, 2003, 16( Suppl 1): 9-13.
  • 3Davis SM, Broderick J, Hennerici M, et al. Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage[J]. Neurology, 2006, 66(8): 1175-1181.
  • 4Ohwaki K, Yano E. Blood Pressure Management in Acute Intracerebral Hemorrhage: Relationship Between Elevated Blood Pressure and Hematoma Enlargement [J]. Stroke, 2004, 35 (6): 1364-1367.
  • 5Fujii Y, Takeuchi S, Sasaki O, et al. Multivariate analysis of predictors of hematoma enlargement in spontaneous intracerebral hemorrhage[J]. Stroke, 1998, 29(6): 1160-1166.
  • 6Gemmati D, Serino ML, Ongaro A, et al. A common mutation in the gene for coagulation factor ⅩⅢ-A(VaI34Leu): a risk factor for primary intracerebral hemorrhage is protective against atherothrombotic disease[J]. Am J Hematol, 2001,67(3): 183-188.
  • 7Corral J, Iniesta J, Gonzalez-Conejero R, et al. Factor ⅩⅢ Va134Leu polymorphism in primary intracerebral haemorrhage [J]. Hematol J, 2000, 1(4): 269-273
  • 8Cho KH, Kim BC, Kim MK, et al. No association of factor ⅩⅢ Va134Leu polymorphism with primary intracerebral hemorrhage and healthy controls in Korean population [J]. J Korean Med Sci, 2002, 17(2): 249-253.
  • 9Endler G, Funk M, Haering D, et al. Is the factory 34Val/Leu polymorphism a protective factor for cerebrovascular disease[J]. Br J Haematol, 2003, 120(2): 310-314.
  • 10Corral J, Gonzalez-Conejero R, lniesta JA, et al. The FⅩⅢ Va134Leu polymorphism in venous and arterial thromboembolism [J]. Haematologica, 2000, 85(3): 293-297.

二级参考文献9

  • 1Anwar R, Gallivan L, Edmonds SD, et al. Genotype/phenotype correlations for coagulation factor ⅩⅢ:specific normal polymorphisms are associated with high or low factor ⅩⅢ specific activity[J]. Blood, 1999,93:897-901.
  • 2Gallivan L, Markham AF, Anwar R. The Leu564 factor ⅩⅢA variant results in significantly lower plasma factor ⅩⅢ levels than the Pro564 variant [J]. Thromb Haemost, 1999,82: 1368-1370.
  • 3Reiner AP, Frank MB, Schwartz SM, et al. Coagulation factor ⅩⅢ polymorphisms and the risk of myocardial infarction and ischaemic stroke in young women[J]. Br J Haematol,2002,116(2):376-382.
  • 4Koichi Suzuki,Jurgen Henke, Misa Iwata,et al. Novel polymorphisms and haplotypes in the human coagulation factor ⅩⅢ Asubunit gene[J]. Hum Genet, 1996,98 : 393-395.
  • 5Alexander P, Stephen M, Schwartz MB, et al. Polymorphisms of coagulation factor ⅩⅢ subunit a and risk of nonfatal hemorrhagic stroke in young white women [J]. Stroke, 2001, 32 ( 11 ): 2580-2586.
  • 6Gemmati D,Serino ML,Ongaro A,et al. A common mutation in the gene for coagulation factor ⅩⅢ-A (VAL34Leu):a risk factor for primary intracerebral hemorrhage is protective against atherothrombotic diseases [J]. Am J Hematol, 2001,67 ( 3 ) : 183-188.
  • 7Attie-Castro FA,Zago MA, Lavinha J,et al. Ethnic heterogeneity of the factor ⅩⅢ Val34Leu polymorphism[J]. Thromb Haemost,2000,84 (4): 601- 603.
  • 8Corral J, Iniesta JA,Gonzalez-Conejero R,et al. No association of factor ⅩⅢ Val34Leu polymorphism with primary intracerebral hemorrhage and healthy controls in Korean population[J]. J Korean Med Sci,2002,17(2) :249-253.
  • 9谢汝萍,杨志杰,于敏,肖卫忠,张新宇,王丽华,张燕,王朝曦,黄因敏,徐希平.凝血因子XⅢ基因Val34Leu突变与脑出血神经功能的相关研究[J].现代康复,2001,5(2):92-93. 被引量：9

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中华神经医学杂志
2008年 第4期

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