摘要
目的 探讨环氧化酶 - 2 (COX - 2 )表达与膀胱癌生物学行为的关系及其意义。方法 采用免疫组化SABC法检测 5 4例膀胱癌、2 9例癌旁组织和 10例正常膀胱粘膜中的COX - 2表达 ,结合临床病理资料进行分析。结果 COX - 2在不同膀胱组织中的表达差异有显著性 (P <0 .0 5 ) ,即膀胱癌组织 >癌旁组织 >正常膀胱粘膜。COX - 2表达随膀胱癌病理级和临床分期的增加而增加 (P <0 .0 5、P <0 .0 1) ,且癌组织中COX - 2表达与淋巴转移有关 (P <0 .0 5 )。结论 COX - 2表达与膀胱癌病理分级、临床分期、淋巴转移有关 ,提示它可能在胱癌的发生、发展中扮演重要角色 ,通过抑制COX - 2活性可能为膀胱癌的防治提供新途径。
Objective:To study the expression of cyclooxygenase-2(COX-2) and relationship with biological behavior of bladder cancer and its clinical significance.Methods:The immunohistochemical SABC method was used to determine the expression of COX-2 in 54 cases of bladder cancer, 29 cases of adjacent nontumorous and 10 cases of normal bladder specimens respectively.Results:The positive expression of COX-2 showed significant difference in different tissues of bladder (P<0.05), and was significantly higher in the cancer tissue.The intensity of COX-2 expression was increased with increasing pathological grades of tumor and clinical stage(P<0.05, P<0.01).There was significant correlation between the lymph node metastasis and expression of COX-2 of bladder carcinoma (P<0.05).Conclusions:The expression of COX-2 is related to the pathological grades, clinical stage, the lymph node metastasis of tumor. This result suggests that cyclooxygenase-2 may be play a role in the development and growth of bladder cancer, the inhibition of cyclooxygenase-2 development may give a new treatment for bladder cancer.
出处
《中国现代医学杂志》
CAS
CSCD
2003年第20期32-34,38,共4页
China Journal of Modern Medicine
关键词
COX-2
膀胱肿瘤
免疫组织化学
Cyclooxygenase-2
Bladder Neoplasms
Immunohistochemistry
