摘要
目的 :探讨Ⅰa期非小细胞肺癌 (NSCLC)手术后早期转移与纵隔淋巴结隐匿性微转移的相关性。方法 :应用RT PCR技术 ,检测 5 0例Ⅰa期NSCLC患者纵隔淋巴结中MUC1基因mRNA的表达 ,诊断纵隔淋巴结隐匿性微转移 ;手术后 12个月内对患者至少复查一次 ,包括胸、脑CT扫描 ,肝、肾上腺B超和骨ECT检查 ,监测早期转移。根据有否淋巴结隐匿性微转移 ,将患者分为两组。χ2 检验比较两组早期转移率的差别 ,计算两组早期转移概率的优势比 (OR值 )。结果 :16例诊断为纵隔淋巴结隐匿性微转移 ,占全部患者的 32 .0 %。纵隔淋巴结隐匿性微转移者的早期转移率 (31.2 5 % )高于淋巴结微转移阴性者 (5 .88% ) ,差别具有显著性 (P <0 .0 5 )。有纵隔淋巴结隐匿性微转移者早期转移的概率是后者的 7倍 (OR =7.2 7)。结论
Purpose:To investigate the correlation between early postoperative metastasis with occult micrometastasis of mediastinal lymph nodes in patients with stageⅠa non small cell lung carcinoma (NSCLC).Methods:Using RT PCR assay, detection of the expression of MUC1 mRNA was used to diagnose occult micrometastasis in mediastinal lymph nodes. All the patients underwent checked up at least once a year to detect early metastatic lesions after surgery, by means of CT scan of chest and brain, ultrasound examination of liver and adrenal glands, and bone scanning. The patients with and without occult nodal micrometastasis were divided into two different groups. Difference in early metastatic rate between two groups of patients was compared by χ 2 test, and odds ratio (OR) was calculated.Results:Occult nodal micrometastasis was diagnosed in sixteen patients (32.0%). Early metastatic rate (31.25%) in the patients with occult nodal micrometastasis was higher than that (5.88%) in the patients without occult nodal micrometastasis ( P <0.05). Possibility of early metastasis in the former was about seven fold higher than that in the latter (OR=7.27).Conclusions:Early postoperative metastasis in patients with stageⅠa non small cell lung carcinoma correlated with occult micrometastasis in mediastinal lymph nodes.
出处
《中国癌症杂志》
CAS
CSCD
2003年第5期423-425,共3页
China Oncology
