摘要
目的：了解非小细胞肺癌（NSCLC）患者术后5年生存率及其影响因素。方法：对1995-2000年新疆肿瘤医院胸外科治疗的128例非小细胞肺癌患者进行为期5年的随访观察,采用寿命表法分析患者术后1-5年生存率及中位生存时间;采用Kaplan-Meire法进行单因素分析;采用log-rank法检验11个影响因素与NSCLC患者生存率的关系;对单因素分析有统计学差异的影响因素用Cox多因素回归模型进行分析。结果：非小细胞肺癌患者1-5年的生存率分别为89.4%、65.4%、45.2%、30.1%、24%,中位生存时间为33.39个月。单因素分析中男性患者肿瘤偏大或虽不大但累及的周围组织、结构较多,有远端淋巴转移是影响非小细胞肺癌患者5年生存的危险因素;对癌肿采取手术治疗、化疗及放疗是其保护因素。多因素分析结果显示性别、手术方式、淋巴转移和病理分期是影响NSCLC患者5年生存的重要因素。结论：性别、手术方式、淋巴转移和病理分期与非小细胞肺癌患者5年的生存有关。
Objective： To study the 5-year survival rate and main factors that influence the survival time of the patients with non-small cell lung cancer （NSCLC）. Methods： From 1995 to 2000, the 128 patients admitted into our department were followed up for 5 years. Survival rate in 5 years were analyzed by Life table. Kaplan-Meire law carries on single factor analysis, adopt log-rank law to examine 11 influence factors which have statistics differences to patient＇s survival rate （α=0.01） or not; The influence factor analysed by single factor analysis which had the statistics difference was analysed with Cox multifactor regression model. Result： The survival rate were 89.4%, 65.4%, 45.2%, 30.1%, 24% respectively in patients with non-small cell lung cancer from 1 year to 5 year. The median survival time was 33.39 months. Single factor analysis showed that male patients whose tumor sizes was bigger or not bigger but involved the peripheral tissues （or structure） and long distant lymph nodes metastasis were the main dangerous factors that influenced the survival time of the patients with non-small cell Lung cancer in 5 years. Surgical operation, chemotherapy and radiotherapy were the chief protect factors in analysing. The sex, operation way, distant lymph nodes metastasis and pathologyical staging in multi-factor analysis were important factors influencing 5 years surviving by stages. Conclusion： The five-year survival rate relates to the pathologiocal stage, sex, operation way and lymph nodes metastasis.
出处
《新疆医科大学学报》
CAS
2008年第1期53-56,共4页
Journal of Xinjiang Medical University
关键词
非小细胞肺癌
生存率
生存因素
non-small cell lung cancer
survival rate
survival factor
