摘要
目的 :探索利培酮治疗精神分裂症最佳剂量。 方法 :将符合精神分裂症诊断标准的患者随机分为 4组 ,分别用每日 2mg、3mg、4mg及 5mg剂量的利培酮治疗 ,疗程 12周。用药前、用药后 1、2、4、6、8、12周末进行阳性症状与阴性症状量表 (PANSS)、临床疗效总评量表 (CGI)、副反应量表 (TESS)、锥体外系副反应量表 (ESRS)评分 ,对各组的疗效、不良反应及影响因素进行探讨。 结果 :4组间疗效差异无显著性 ,不良反应差异却有非常显著性。 结论 :利培酮 2～ 4mg是治疗精神分裂症的理想剂量。
Objective:To evaluate the optimum dosage of risperidone in the treatment of schizophrenia. Method:173 schizophrenic patients diagnosed according to CCMD 2 R were randomly assigned to treatment with 2mg,3mg,4mg or 5mg of risperidone daily.Mental symptoms were assessed at baseline and at the end of 1,2,4,6,8,12 week with the positive and negative symptom scale (PANSS),clinical global impression (CGI).Side effects were assessed with the treatment emergent symptom scale(TESS),the extrapyramidal symptom rating scale(ESRS) and experimental assays. Results:No statistical differences in clinical improvement were found among the 4 dosages.But there were significant differences in the side effects among different dosages. Conclusion:The dosage of 2mg～4mg of risperidone is optimal in the treatment of schizophrenia.
出处
《临床精神医学杂志》
2003年第5期296-297,共2页
Journal of Clinical Psychiatry
