摘要
肺纤维化是以肺成纤维细胞增殖及细胞外基质聚集为特征的病变 ,对人的健康和生命危害极大 ,因其确切发病机制仍不十分清楚 ,而给防治带来极大困难。目前已知肺纤维化发生与肺成纤维细胞的间隙连接通讯功能下调、纤维化相关基因及群体基因、多种细胞生物因子的异常表达和纤维化相关信号转导途径的激活等有一定关系。因此阐明其发病机制对肺纤维化的有效防治具有指导意义。本文就近年关于肺纤维化的发生机制和早期防治研究进展进行综述。
Pulmonary fibrosis is a pathologic change characterized by fibroblast proliferation and extracellular matrix accumulation, and it is extremely harmful to people′s health and life. It is difficult in prevention and treatment of pulmonary fibrosis because its pathogenesis is still not very clear. According to present acknowledge, pulmonary fibrosis is related to disruption of fibroblast “gap junction information communication', abnormal expression of fibrogenesis related gene and group genes, and cellular biological factors and activation of fibrosis_related signal transduction pathway,so clarification of exact pathogenesis possesses a direct role for effective prevention and treatment of pulmonary fibrosis. Recent studies on the molecular mechanisms, early prevention and treatment of pulmonary fibrosis are reviewed. [
出处
《军事医学科学院院刊》
CSCD
北大核心
2003年第4期312-316,共5页
Bulletin of the Academy of Military Medical Sciences
基金
军事医学科学院开发研究基金 ( 2 0 0 3 )
关键词
肺纤维化
机制
基因
信号转导
防治
pulmonary fibrosis
pathogenesis
genes
signal transduction
prevention and treatment
