摘要
目的 :观察预注小剂量麻黄素预防老年人硬膜外麻醉下截石位术毕放腿时的低血压反应。方法 :2 7例经尿道前列腺电切腔镜手术 (TURP)老年患者 ,随机分为预注组 (n =13)和对照组 (n =14 ) ,T12 -L1及L3 -4两点穿刺置管 ,阻滞用药 1.5 %利多卡因。术毕 ,患者放双腿平卧前 30s预注组静注 15mg麻黄素 ,对照组静注盐水 3ml ,记录 10min内患者每分钟收缩压 (SBP)、舒张压 (DBP)、平均动脉压(MAP)、心率 (P)、心电图 (EKG)、脉搏血氧饱和度(SpO2 )变化。结果 :预注组 10min内SBP、MAP、P呈轻度升高者 10例 ,占 76 .9% ,平均升幅 8.7% ,对照组 1～ 5minSBP、MAP下降者 12例 ,占 85 .7% ,平均降幅 7.8% ,两组变化的百分率比较P <0 .0 1或P <0 .0 5。结论 :老年硬膜外麻下截石位术毕放腿前 30s预注麻黄素 15mg 。
AIM: To observe the effect of small dose ephedrine on hypote ns ion as the lithotomy position in laying down legs after the aged in the operatio ns with epidural anesthesia. METHODS: Twenty-seven ASA Ⅰ-Ⅱma le patients, aged 65-83 (71± 6.5 ) years undergoing transurethral resection of prostate (TURP) with the lithotomy position were randomly assigned to two gro ups by double blind method: ephedrine group (n=13) and contrasti ve group (n=14). The continual epidural anesthesia was administe red in T 12 -L 1 and L 3-4 for all patients used 1.5 % lidocaine. W hen the operation was finished off, before thirty seconds of horizontal position laying down legs, 15 mg ephedrine was iv at ephedrine group and 3 ml saline wat er at control group. After legs were laid down on the lithotomy position, variab les of SBP, MBP and P were recorded in ten minutes. RESULTS: Dur ing ten minutes after double legs were laid down, the variables were lightly ris en about 8.7 % to 76.9 % in ephedrine group and were fallen about 7.8 % to 85.7 % in control group. The difference on variables of two groups was significant (P< 0.01 or P< 0.05 ). CONCLUSION: It is effective of 15 mg ephetrine by injection before thi rty seconds after aged in the operations with epidural anesthesia to prevent the hypotension as changing the lithotomy position in laying down the legs.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2003年第6期673-676,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
药效学
硬膜外麻醉
老年人
截石位
低血压
麻黄素
pharmacodynamics
epidural anesthesia
aged
lithotomy posi tion
hypotension
