摘要
目的 探讨阿尔茨海默病 (AD)P3 0 0 的特点以及P3 0 0 与简易智力状况检查 (MMSE)评分的相关性。方法 对 32例AD患者和 30名健康老年人应用NicoletBravo脑诱发电位仪进行事件相关电位P3 0 0 检测 ;同时用MMSE进行认知功能评估。结果 (1)AD组MMSE评分 [(16 5 2± 2 17)分 ]低于正常对照组 [(2 6 5 7± 1 4 3)分 ,P <0 0 1]。 (2 )AD组与正常对照组相比 ,靶刺激中的P2 、N2 、P3 潜伏期长 ,P2 、P3 波幅低 ;非靶刺激P2 波幅低 (P <0 0 5～ 0 0 1) ;AD组Cz、Pz、Fz各点间的P3 0 0 指标相比 ,差异均无显著性 (P >0 0 5 )。 (3)AD组P3 0 0 靶刺激中的P2 、P3 波潜伏期与MMSE分值呈负相关 (P <0 0 5～ 0 0 1)。结论 AD患者的P3 0 0 有多指标变异 ,且与其认知功能缺损的程度有关。
Objective To study the characteristics of P_ 300 event-related potential component, and the correlation between P_ 300 index and the Mini-Mental State Examination (MMSE) score in patients with Alzheimer′s disease (AD). Methods Thirty-two patients met the NINCDS-ADRDA criteria for probable AD and 30 normal controls (NC) matched with gender, age, and educational level, were entered in the study. P_ 300 was tested with American Nicolet Bravo Instrument, and MMSE assessed meanwhile. Results (1) The AD patients had lower MMSE score than the NCs ( P <0.01). (2) The latencies of P_ 300 subcomponents P_2, N_2 and P_3 were significant delayed and the amplitudes of P_2 and P_3 decreased in AD patients compared with those in NCs ( P <0.05-0.01). The variations of P_ 300 index between the Cz, Pz, Fz sites were not significantly different in AD patients. (3) The delayed P_2 and P_3 latencies were negatively correlated to MMSE score ( P <0.05-0.01). Conclusion Some P_ 300 index are variant in AD patients and correlated with the cognitive impairment severity.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2003年第3期172-175,共4页
Chinese Journal of Psychiatry
