摘要
目的 探讨彩色多普勒能量图 (CDPI)血流检测及血管内皮生长因子 (VEGF)表达对乳腺肿块中血管生成的判定作用以及二者的相关关系。方法 对 1 0 3例乳腺肿块术前行CDPI血流检测 ,术后标本行免疫组化法检测VEGF的表达。结果 CDPI血流检测乳腺肿块的阳性率为 83 .5 % (86/ 1 0 3) ,其中乳腺癌检出阳性率为 1 0 0 % (66/ 66)远远高于良性肿块的阳性率 54 .1 % (2 0 / 37) (P <0 .0 0 5) ;VEGF在乳腺癌的表达阳性率 1 0 0 % (66/ 66)远远高于良性肿块的表达阳性率 8.1 % (3/ 37) (P <0 .0 0 5) ,有淋巴结转移组表达强度明显高于无淋巴结转移组 (P <0 .0 0 5)。乳腺癌中CDPI血流检出率与VEGF表达阳性率呈正相关关系 (P <0 .0 0 5)。结论 血管形成与乳腺癌的生长、浸润和转移有密切关系 ,CDPI血流检测对于乳腺肿块良恶性的鉴别有重大意义 ,而且CDPI与VEGF的联合检测为判定肿瘤内血管形成水平的有效指标之一。
Objective To study the role of CDPI examination and VEGF expression in the angiogenesis of breast neoplasm and their relationship. Methods We investigated all 103 cases blood signal with CDPI and VEGF expression by immunohistochemical stain. Results There are singnificant difference of CDPI blood signal and VEGF expression between breast cancinoma and neoplasm(P<0.005), The increased VEGF expression with lymph node metastasis is much higher than that without lymph node metastasis(P<0.005). A close correlation was found between CDPI blood signal and VEGF expression to angiogenesis in breast carcinoma(P<0.005). Conclusion The study indicated that breast carcinoma angiogenesis was closely correlated to the growth, invasion and metastasis.CDPI examination and VEGF expression may be a useful indicator to angiogenesis in breast carcinoma.
出处
《中国煤炭工业医学杂志》
2003年第9期801-802,共2页
Chinese Journal of Coal Industry Medicine
