摘要
①目的 观察原发性高血压 (EH)不同危险度分层病人血浆肾上腺髓质素 (ADM)、内皮素 1(ET 1)及假性血友病因子 (VWF)含量变化及其临床意义。②方法 随机选取不同危险度分层高血压病人 80例 ,分别测定治疗前后血浆ADM、ET 1、VWF含量的变化 ,并与 2 0例正常人测定结果比较。③结果 治疗前不同危险度分层高血压病人血浆ADM、VWF、ET 1含量均高于对照组 ,差异有显著性 (F =6 .2 3～ 17.0 8,q =4 .2 7～ 10 .4 3,P <0 .0 5 ) ,且随危险度增加而增高 (q=3.87～ 6 .86 ,P <0 .0 5 ) ;ADM含量与VWF、ET 1含量呈正相关 (γ =0 .6 0 2、0 .6 83,P <0 .0 1)。治疗后各组ADM、VWF、ET 1含量较治疗前降低 ,差异有显著性 (t=3.71～ 2 0 .80 ,P <0 .0 1)。④结论 ADM、VWF、ET 1参与了高血压的发生发展 ,正规有效治疗可降低ADM、ET 1、VWF的水平。
Objective\ To study the relationship between the risk stratification in essential hypertension(EH) and the levels of plasma VWF, ADM and ET 1, and explore the clinic significance. \ Methods\ Eighty EH patients with different risk stratification were randomly selected for this study. The plasma VWF,ADM and ET 1 were detected and compared with 20 normal controls. \ Results\ Before treatment ,the levels of plasma VWF, ET 1, ADM increased significantly in EH group compared to that of the control group, the difference was significant ( F=6.23-17.08, q=4.27-10.43, P <0.05), and the levels of VWF, ET 1 And ADM elevated with the increase of the risk ( q=3.87-6.86, P <0.05). The levels of ADM, ET 1 and VWF were lower than that of before treatment, the difference showed great difference ( t= 3.71-20.8, P <0.05). \ Conclusion\ ADM, ET 1 and VWF are involved in the occurrence and development of essential hypertension. Proper therapy can lower the levels of ET 1, ADM and VWF.
出处
《青岛大学医学院学报》
CAS
2003年第3期312-314,共3页
Acta Academiae Medicinae Qingdao Universitatis
