摘要
目的 观察紫红獐牙菜对小鼠慢性肝损伤的保护作用。方法采用CCl_4造成小鼠慢性肝损伤,测定小鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和总蛋白的含量,同时观察肝组织病理变化。结果 紫红獐牙菜能明显降低血清ALT、AST的含量(P<0.001)及增加总蛋白含量(P<0.05,0.01),随着造模时间延长,作用更明显,能缓解肝组织纤维化,降低肝脏指数,对脾脏指数无明显影响。结论紫红獐牙菜对CCl_4慢性肝损伤具有一定保肝降酶,延缓和减轻肝纤维化的形成。
Objective To observe the protective effect of Swertia Punicea Hemsl. on mice chronic hepatic injury induced by CCI_4. Methods Serum levels of ALT, AST and total protein were measured and the liver index, spleen index as well as hepatic pathological changes were also observed. Results Swertia Punicea Hemsl. obviously decreased the levels of serum ALT and AST(P<0.001) and increased the content of total protein (P<0.05 or P<0.01) in a time-effect manner. The drug decreased the liver index and relieved the hepatic fibrosis but had no effect on the spleen index. Conclusion Swertia Punicea Memsl. can protect hepatic function, decrease transaminase and can delay or reduce the progress of hepatic fibrosis.
出处
《中药新药与临床药理》
CAS
CSCD
2003年第5期304-306,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
云南省教委资助项目(编号 9912060)
关键词
紫红獐牙菜/药理学
肝纤维化/中药疗法
疾病模型
动物
@ Swertia Punicea Hmsl./pharmacology
@ Liver fibrosis/drug therapy
Disease models,animal
