摘要
目的 观察口服肝炎灵对实验性慢性肝损伤的治疗作用。方法 用四氯化碳建立大鼠慢性肝损伤模型 ,造模 7周后同时予口服或静注肝炎灵治疗。结果 口服或静注肝炎灵后均可使慢性肝损伤大鼠的ALT、AST值及肝脏羟脯氨酸含量下降 ,血清白蛋白和A/G比值增高。组织学检查显示该药可减少肝细胞脂肪变性和坏死 ,抑制肝间质的纤维增生。结论 肝炎灵可减轻慢性肝损伤程度 。
Objective To observe the therapeutic action of Gangyanling on experimental chronic liver injury.Methods The models of chronic liver injury in rats were set up with CCl 4,and 7 weeks later treated with Ganyanling both by ig or ip for 12 weeks.Results Use of Ganyanling by ig or ip was able to decrease ALT,AST and liver hydroxyproline levels in chronic injury rats,and increase the serum albumin level and the ratio of A/G.Histology examination indicates that Ganyanling was able to lessen degeneration and necrosis of liver cells,and inhibit the proliferation of fibrous tissue in liver.Conclusion Ganyanling given by ig or ip both can relieve the degree of chronic liver injury,which has the function to reduce the harm of free radical to liver cells and the function of anti-fibrosis in liver.
出处
《苏州医学院学报》
2001年第5期517-519,共3页
Acta Academiae Medicinae Suzhou
关键词
肝炎灵
慢性肝损伤
羟脯氨酸
治疗
中药
Ganyanling
chronic liver injury
hydroxyproline
therapeutic function
