摘要
目的:观察乙肝Ⅱ号治疗慢性乙型肝炎的临床疗效,并探讨其作用机理。方法:采用乙肝Ⅱ号治疗慢性乙型肝炎60例,并与乙肝宁颗粒剂组26例作对照,同时进行实验研究,观察乙肝Ⅱ号对实验性肝损伤及免疫性肝损伤小鼠抗氧化功能的影响。结果:临床治疗组治疗后症状积分及血清ALT、AST、TBIL有明显改善(P<0.05),HBeAg阴转率达41.7%,HBV-DNA阴转率达35%,均优于对照组(P<0.05);实验研究表明,乙肝Ⅱ号防治组与模型组相比,肝损伤明显减轻,血清(肝匀浆)MDA含量下降,SOD活力上升,GSH-PX活力上升,变化程度与用药量呈明显的量效关系,且抗自由基的作用优于乙肝宁颗粒剂组。结论:乙肝Ⅱ号对慢性乙型肝炎患者有明显疗效,其机理可能与抑制过氧化反应有关。
Objective: To observe the clinical effect of treatment of chronic virus hepatitis B with Hepatitis B Mixture(HBMⅡ), and to explore its mechanism. Methods:60 case of chronic virus hepatitis B were treated with HBMⅡ compared with 60 case of chronic virus hepatitis B were treated with Yi Gan Ling. At the sametime, experimental study were observed, HBMⅡ Was studied for its antioxidation in experimental hepatic injury. Results:HBMⅡ showed some inhibitory effect on changes of Aminotranssferase (ALT and AST). The decrease ratio of HbeAg positive and HBV-DNA position was 41.7% and 35% respectively. Compared with control animals, HBMⅡ can dose dependently inhibit the increased malonyldialdehyde(MDA) and the decreased superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX). Conclusion:HBMⅡshowed some antioxidation and received effect of hepatic cells on patients with chronic virus hepatitis B.
出处
《中国中医药信息杂志》
CAS
CSCD
2001年第9期47-49,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
江苏省科委课题(BS96355)
关键词
乙肝Ⅱ号
慢性乙型肝炎
实验性慢性肝损伤
免疫性肝损伤
谷胱甘肽过氧化物酶
超氧化物歧化酶
治疗
Hepatitis B Mixture(HBMⅡ)
Antioxidation
chronic virus hepatitis B
Superoxide dismutase (SOD)
Malonyldialdehyd(MDA)
Glutathione peroxidase (GSH-PX)
Aminotranssferase (ALT, AST)
