摘要
目的:探讨血清肿瘤标志物癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21鄄1)、神经元特异性烯醇化酶(NSE)联合检测在原发性支气管肺癌诊断中的价值。方法:采用放射免疫法检测149例原发性支气管肺癌和30例良性肺病患者血清中CEA、CYFRA21鄄1、NSE的水平。结果:肺癌组CEA、CYFRA21鄄1、NSE测定值显著高于对照组(P<0.01)。3项测定的阳性率与病理类型有关,CEA以腺癌最高(62.1%),CYFRA21鄄1以鳞癌最高(62.2%),NSE以小细胞癌最高(52.0%),分别与其他病理类型相比差异显著(P<0.01)。Ⅲ、Ⅳ期血清CEA、CYFRA21鄄1、NSE水平均高于Ⅰ、Ⅱ期(P<0.01)。3项联检阳性率均高于单项和两项联合检测的阳性率,3项联检可使早期肺癌的诊断率提高到50%。结论:CEA、NSE、CYFRA21鄄1是诊断肺癌有价值的肿瘤标志物,3项联合检测可提高肺癌的诊断率。
To evaluation clinical value of combined detection of serum CEA,NSE and CYFRA21-1in patients with lung cancer.Methods:CEA,NSE and CYFRA21-1were assayed in149patients with lung cancer and30patients with benign lung disease(BLD)using radioimmunoassay.Results:The serum levels of CEA,NSE and CYFRA21-1in pa-tients with lung cancer were much higher than those in patients with BLD(P<0.01).The positive rates of CEA in adeno-carcinoma,CYFRA21-1in squamous carcinoma and NSE in SCLC were62.1%,62.2%and52.0%,respectively(P<0.01).The serum levels of CEA,NSE and CYFRA21-1in stageⅢand stageⅣpatients were much higher than that in stageⅠand stageⅡpatients(P<0.01).The positive rates of combined detection of CEA,NSE and CYFRA21-1were higher than those of detecting1or2of the above3.The positive rates of the combined detection for early diagnosis of lung cancer increased from14.3%-17.9%to50.0%.Conclusion:CEA,NSE and CYFRA21-1combined detection can increase the diagnosis rate for lung cancer.
出处
《诊断学理论与实践》
2003年第3期200-202,共3页
Journal of Diagnostics Concepts & Practice
关键词
血清
CEA
CYFRA21-1
NSE
联合检测
肺癌
诊断
Lung cancer Tumor marker Carcinoma-embryon antigen Cytokeratin19fragment Neuron-specific enolase
