摘要
目的 :通过检测脑转移瘤患者治疗前后血清和脑脊液中NSE的含量 ,比较两者的变化对脑转移瘤的诊断及预后的临床意义。方法 :用放射免疫分析法检测脑转移患者治疗前后及对照组中血清及脑脊液NSE水平的变化。结果 :脑转移瘤患者治疗前血清NSE水平为 34 8 2± 139 7μg/ml,阳性率 6 7 9%。脑脊液NSE水平为 476 1± 132 3μg/ml,阳性率为 89 3% ,治疗后血清NSE水平为 2 71 3± 89 1μg/ml,阳性率为 2 3 2 % ,脑脊液中NSE水平为 16 2 5± 72 5 μg/ml,阳性率为 16 1% ,且脑转移瘤患者治疗前后水平差异明显 (P <0 0 0 1)。结论 :上述研究结果表明 ,检测患者血清及脑脊液中NSE水平有助于脑转移瘤的诊断及疗效的判定。
Objective:To study the diagnostic value of NSE in the serum and cere brospinal fluid(CSF) of patients with brain metastases methods.Methods:By the methods of radioimmunoassay(RIA), the ceuec of NSE in the serum and CSF of brain metastases and healthy control were measured. The relationship between the NSE level and clinical features of patients was also studied.Results:The NSE levels in the serum and CSF of patients with brain metastases were significantly higher than those of control group.(positive rate of the former is 67 9%,89 3%; the later is 23 3% and 16 1% respectively(P<0 001). The NSE level of post treatment is markably reduced.Conclusion:The results showed that NSE in serum is helpful for diagnosing Brain metastases and can be used for judging the effectiveness of treatment.
出处
《临床肿瘤学杂志》
CAS
2002年第2期117-118,120,共3页
Chinese Clinical Oncology
