摘要
目的 :探讨儿童颅内感染脑脊液白细胞介素 2 (IL - 2 )、肿瘤坏死因子 -α(TNF -α)的变化及意义。方法 :采用双抗体夹心Elisa方法 ,检测 4 4例颅内感染者脑脊液中IL - 2、TNF -α的浓度。结果 :化脓性脑膜炎IL - 2、TNF -α浓度明显高于结核性和病毒性脑膜炎 (P <0 .0 1)结核性脑膜炎脑脊液中IL - 2、TNF -α发生异常的比率明显高于化脓性和病毒性脑膜炎 (P <0 .0 1)。结论 :IL - 2、TNF -α作为免疫因素参与颅内感染疾病的发生过程 ,对颅内感染疾病的鉴别诊断具有一定意义。
Objective: To investigate the variations of cerebrospinal fluid (CSF) interleukin-2(IL-2) and tumor necrosis factor-α(TNF-α) levels in children with intracranial infections. Method: The concentrations of IL-2 and TNF-α were measured in the CSF of 44 children with intracranial infections by enzyme-linked immunosorbent assay. Results: The CSF levels of IL-2 and TNF-α were higher in patients with purulent meningitis than those of tuberculous meningitis or virus meningitis (P<0.01). The incidence of abnormality of IL-2 and TNF-α in the CSF was higher in tuberculous meningitis group than those of purulent or virus meningitis group (P<0.01). Conclusion: There were significant differences of the CSF levels of IL-2 and TNF-α between purulent meningitis group and the others. It is suggested that the CSF levels of IL-2 and TNF-α may play an important role in the pathogenesis of intracranial infections and can serve as a marker for differential diagnosis.
出处
《河北医学》
CAS
2003年第7期579-581,共3页
Hebei Medicine
