摘要
报道了以 5 异丁基 2 氨基 1,3 ,4 噻二唑和异硫氰酸苯酯为原料 ,乙腈为溶剂 ,溴化十六烷基三甲基铵为催化剂合成 1 (5 异丁基 1,3 ,4 噻二唑基 ) 3 苯基硫脲。得到的较好工艺条件为 :n(5 异丁基 2 氨基 1,3 ,4 噻二唑 )∶n(异硫氰酸苯酯 ) =1∶1.8,水浴加热回流 4h ,每 10mmol 5 异丁基 1,3 ,4 噻二唑的催化剂用量 2g ,在此条件下产率为 5 3 .71%。并对合成产物进行了抗菌实验 。
Isobutyl 1,3,4 thiodiazolyl) 3 phenyl thiourea was synthesized from 2 amino 5 isobutyl 1,3,4 thiodiazole and phenyl isothiocyanate with cetyl trimethyl ammonium bromide as catalyst and acetonitrile as solvent. The results showed that the optimum synthetic conditions were as follows: molar ratio of 2 amino 5 isobutyl 1,3,4 thiodiazole to phenyl isothiocyanate = 1∶1.8, reaction time 4 h, amount of catalyst 2 g/10 mmol 2 amino 5 isobutyl 1,3,4 thiodiazole, the yield of the title compound was 53.71%. The antimicrobial tests showed that it has antibiotic activity to Brevibacterium.
出处
《精细石油化工》
CAS
CSCD
北大核心
2003年第4期40-42,共3页
Speciality Petrochemicals
基金
江西省教育厅科技课题项目 ( 2 0 0 0 4 4)
