摘要
本文对12例头颈癌患者、19例肥厚性鼻炎及14例正常人进行了外周血 T 淋巴细胞亚群、血清免疫球蛋白及补体 C_3的测定。结果表明:头颈癌组 OKT_3、OKT_4值均较正常对照组降低。P 均<0.05,OKT_8较正常略有升高,但 P>0.05,OKT_4/OKT_8比值较正常组明显降低,P<0.01。而肥厚性鼻炎组 OKT_3、OKT_4和 OKT_8与正常组相比均无差异。提示,头颈癌病人的免疫功能下降主要由 OKT_3、OKT_4下降所致。用单扩散法测定 Ig 及 C_3含量,结果显示各组间均无显著差异。
The levels of T—lymphocyte subpopulations,Ig and complement C_3 in peripheral blood were checked in
12 cases of progressive head and neck cancer(HNC),19 cases of chronic hypertrophic rhinitis and 14 normal
individuals.The results showed that the levels of OKT_3 and OKT_4 of HNC group were lower(P<0.05)and
OKT_8 was slightly higher(P>0.05)than that of controled group.The ratio of OKT_4/OKT_8 decreased sig-
nificantly(P<0.01).There were no differences in OKT_3,OKT_4 and OKT_8 between chronic hypertrophic
rhinitis group and control group.The results suggested that immune function of HNC patients decreased
mainly by diminution of OKT_3 and OKT_4.The levels of Ig and complement C_3 had no obvious differences in
all three groups.
出处
《兰州医学院学报》
1992年第2期101-103,共3页
Journal of Lanzhou Medical College
关键词
头部肿瘤
T细胞亚群
免疫球蛋白
Cancer
head and neck
T—lymphocyte subpopulation
Ig
C_3
