摘要
本文应用免疫扩散法及 C_3单扩散板测定舌鳞癌患者手术前后血清 Ig 及 C_3含量,与正常对照组比较及手术前后相比差异均不显著(P>0.05),提示舌鳞癌患者的体液免疫功能影响不明显。而应用 OKT 系列单克隆抗体以间接免疫荧光法对舌鳞癌患者手术前后的外周血 T 细胞亚群进行检测,结果表明,OKT_4/OKT_(?)细胞比值由1.28±0.19升至1.42±0.03(P<0.01)可较为客观地反映患者体内的细胞免疫功能状态,可作为判断舌鳞癌患者免疫状态的指标。
T cell subsets in peripheral blood and Ig and C_3 in serum in 10 cases of patients with tongue squa- mous carcinoma were determined by indirected immunologic fluorescence and IEP respectively.The results showed that there were no difference in serum Ig and C_3 between 10 patients and 24 normal controls.Compared with normal controls,the percentages of OKT_3 and OKT_4 were much lower and the percentage of OKT_8 was much higher in patients,so the ratio of OKT_4/OKT_8 decreased significantly(P <0.01).After two weeks of operation,the percentage of OKT_3 tended to increase,but the percentages of OKT_4 and OKT_8 were higher and lower than those in preoperative period respectively(both P< 0.05).Our findings indicate that tongue squamous carcinoma has little effect on humoral immunity and removal of carcinoma can improve cellular immunity.The ratio of OKT_4/OKT_8 is one of more objective indexes reflecting the function of human cellular immunity in patients with tongue squamous carcinoma.
关键词
舌鳞癌
手术
免疫功能
tongue squamous carcinoma
immunoglobulin
C_3
T cell subsets
OKT McAb
