摘要
目的 :比较加替沙星片与左氧氟沙星片治疗轻、中度急性下呼吸道感染的有效性和安全性。方法 :经临床确诊的轻、中度急性下呼吸道感染患者39例 ,其中加替沙星组 2 0例 ,口服加替沙星片0 .2g ,2次 d ;左氧氟沙星组 19例 ,口服左氧氟沙星片 0 .2g ,2次 d ,疗程均为 5～ 10d。结果 :加替沙星组和左氧氟沙星组痊愈率分别为 75 % (14 2 0 )和73.7% (14 19) ,有效率分别为 95 %和 94 .7% (P >0 .0 5 ) ,两组细菌清除率分别为 10 0 %和 90 % (P >0 .0 5 )。两组间临床和细菌学疗效差异无显著性。两组不良事件发生率分别为 10 .0 %和 10 .5 % ,主要为消化道反应。加替沙星组有 4例 (2 0 .0 % )、左氧氟沙星组有 5例 (2 6 .3% )出现谷丙转氨酶的轻度升高 ,但不影响治疗。结论 :加替沙星片能安全有效地治疗轻、中度急性下呼吸道感染。
AIM: To compare efficacy and safety of gatifloxacin and levofloxacin by a randomized controlled trial in treatment of patients with light to moderate acute lower respiratory tract infections. METHODS: 39 cases were assigned to two groups: 20 in gatifloxacin group and 19 in levofloxacin group. The dose of gatifloxacin was 0.2 g per tablet, po, two times a day and the same to levofloxacin. The course of treatment was 5-10 d. RESULTS: The clinical curative rates of gatifloxacin and levofloxacin groups were 75% (14/20) and 63.16 % ( 12/19 ), the effective rates were 100% and 90% (P> 0.05 ), bacterial clearance were 100% and 90%, and adverse reaction rates were 10%(2/20)and 10.53 % ( 2/19 ), respectively. All those adverse reactions were mainly gastrointestinal tract reactions. The abnormality of laboratory inspections associated with trial drugs happened to 4 and 5 patients in two groups. The reactions were mostly light increase of aminotransferase without effect on therapy. CONCLUSION: Gatifloxacin is an antibiotic with large antimicrobial spectrum and can be recommended to treat light to moderate acute lower respiratory tract infections.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2003年第4期434-437,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
药效学
加替沙星
左氧氟沙星
随机对照研究
急性下呼吸道感染
pharmacodynamics
gatifloxacin
levofloxacin
randomized controlled trial
acute lower respiratory tract infections
