摘要
【目的】探讨左氧氟沙星与加替沙星治疗呼吸道感染的有效性与安全性。【方法】对符合纳入标准的左氧氟沙星与加替沙星治疗呼吸道感染的文献，进行Meta分析，以·】盏床总有效率、细菌清除率、不良反应发生率为指标。【结果】共检索到13个试验，包括968名患者。左氧氟沙星与加替沙星临床有效率、细菌清除率、不良反应发生率meta分析结果分别为ERR0．79，95％CI（0．48，1．31），P0．37]、[RR0．69，95％CI（0．37，1．31），P0．27]、ERR0．77，95％CI（0．54，1．10），P0．15]。【结论】研究表明左氧氟沙星与加替沙星治疗呼吸道感染的临床疗效、细菌清除率及不良反应发生率均无显著性差异。
[Objective] To explore the effectiveness and safety of levofloxacin and gatifloxacin for the treat- ment of respiratory tract infection. [Methods]The literatures of levofloxacin and gatifloxacin for the treatment of respiratory tract infection in accordance with the inclusion criteria were collected for Meta analysis. The total effec- tive rate, bacterial eradication rate and the incidence of adverse effects were chosen as the indicators. [Results] Thirteen trials were retrieved. There were 968 patients. The comparison of clinical effective rate, bacterial eradi- cation rate and the incidence of adverse reaction between levofloxacin and gatifloxacin were [RR 0, 79, 95% CI （0.48,1.31）, P 0.37],[-RR 0.69, 95% CI（0.37,1.31）, P0.27] and [RR0.77, 95%CI（0.54,1.10）, P0. 15]. [ConclusionlThe study indicates that there is no significant difference in clinical efficacy, bacterial eradication and incidence of adverse reaction between levofloxacin and gatifloxacin.
出处
《医学临床研究》
CAS
2013年第4期670-674,共5页
Journal of Clinical Research
