摘要
目的 :对健胃口服液的毒理学进行动物实验研究 ,观察其健脾和胃、理气消食的功效。方法 :急性毒性试验 :取 6 0只小鼠以 2倍于原浓度 3.6ml/ 2 0 g/d的剂量 ,分 4次给药 ,0 .9ml/次 ,一次性给药后观察 7d ,观察毒副作用的反映。长期毒性试验 :按不同剂量分 4个组进行观察 ,口服给药 ,1次 /d ,连续 1 2周 ,于停药后 7d进行血液学测定。结果 :急性毒性试验表明 :测得最大耐受量≥ 36 0g/kg ,此剂量是成人 (以 6 0kg计 )临床日口服剂量 0 .5g/kg的 70 0倍 ,属实际无毒。长期毒性试验表明 :服用健胃口服液可导致食欲增加 ,从而使体重增加。但从体重分析表明 ,除高剂量组差异明显外 ,中、低剂量组均无明显差异 ,但对血液学指标、肝。
Objective: To do toxicologic study on animals in order to observe its functions of regulating spleen and stomach, regulating flow of qi, and promoting digestion. Method: The animal experiment on its toxicity indicates the optimum tolerance was or over 360g/kg in the acute toxicity, which is 700 times of the clinical oral dosage (0.5g/kg) per day for adults (60kg). This actually means this oral solntion has no toxic effect. In terms of the toxicity test on a long-term basis, the administration of this liquid led to increased appetite and in turn the increase in weight. An analysis of the weight shows no marked difference except in the large dosage group, but this difference did not affect the indexes of hematology and functions of the liver and kidney as well as the coefficient of the organs.
出处
《河南中医学院学报》
CAS
2003年第3期23-24,共2页
Journal of Henan University of Chinese Medicine
关键词
健胃口服液
毒理学
研究
中药
Stomach-Tonic Oral Liquid
toxicology
experimental study
