摘要
用7～30周人胚胎71例,新生儿3例,以组织学、组织化学及免疫金银法研究胃的组织发生。结果发现,7周胚胃上皮为复层柱状,含大量糖原颗粒。9周胚出现单层柱状上皮、胃小凹及胃腺原基,腺底部可见少数壁细胞。胃窦幽门腺也有壁细胞。13～14周,胃窦及胃底相继出现粘膜肌,能分辨胃壁的4层结构。12周时,胃底和胃窦已出现少数嗜银细胞,分散存在于表面上皮或集中于腺下部,呈圆形、锥形和梭形。14周始,胃窦嗜银细胞比胃底多,18周时嗜银细胞最多,其中有的细胞具有突起伸向壁细胞或基膜。15～30周,胃底EC细胞形态多样,有开放型EC细胞。13、16、21周胃窦G细胞呈圆形或锥形,有聚集成群现象。电镜下观察到胃窦有发育中的G细胞。
In this article we collected 2 embryos and 69 fetuses between 7 and 30 weeks of gestational age and 3 neonates to study the development of the human stomach by histological, histochemical and immunogold-siver methods. In 7-week embryo, the superficial layer of gastric mucosa was stratified columnar epithelium, containing a large amount of glycogen. In 9-week fetus, simple columnar epithelium, gastric pits and glandular buds were observed. At this stage a few parietal cells could be identified at the bottom of the glands. The pyloric glands contained parietal cells as fundic glands. At 13-14 week the muscularis mucosa appeared and the wall of stomach formed definitively as the adult. A few argyrophil cells in antrum and fundus were found at 12-week fetus. They scattered in the surface epithelium and concentrated in the lower portion of the glands. The argyrophil cells were round, pyramidal or spindle in shape. More argyrophil ceils were found in the antrum from 14-week on. At 18-week, the argyrophil cells were most numerous. Some cells possessed processes extending to the basement membrane or parietal cells. Between 15-30 weeks various shaped EC cells in fundus were found, with some open-type endocrine cells. G cells in antrum were mostly rounded and often in groups at 13,16 and 21 week. Developing G cells were observed under EM.
出处
《解剖学报》
CAS
CSCD
北大核心
1992年第3期325-329,共5页
Acta Anatomica Sinica
基金
国家自然科学基金
关键词
胃
组织发生
EC细胞
G细胞
人胚
Stomach
Histogenesis
EC cell
G cell
Human embryos and neonates
