摘要
目的 :观察干扰素α 2a(interferonα 2a)栓治疗宫颈糜烂的疗效。方法 :宫颈糜烂病人 35 6例 ,年龄 (32±s 11)a ,随机分为A组 140例 ,应用干扰素α 2a栓阴道放置 ,隔日 1次 ,9枚为一个疗程 ,共2疗程。B组 12 2例 ,采用光热治疗。C组 94例 ,光热治疗后应用干扰素α 2a栓 2个疗程。治疗 3mo后观察各组疗效 ,6mo后观察复发数。结果 :A ,B ,C 3组痊愈例数分别为 116,99,82例 ,3种治疗方法间的疗效无显著差异 (P >0 .0 5 ) ;A ,B ,C 3组复发数分别为 10 ,15 ,7例 ,3组间差异无显著意义 (P >0 .0 5 ) ;A组不良反应明显较B ,C组轻。结论 :干扰素α 2a栓治疗宫颈糜烂效果与光热治疗、干扰素栓加光热治疗相似 ,但不良反应小、方便易行 。
AIM: To observe the clinical effects of interferon α-2a for treatment of patients with cervical erosion. METHODS: Three hundred and sixty-five outpatients, with cervical erosion (age (32±s 11 a))were randomly divided into three groups (A,B,C). One hundred and forty patients in A group were treated with interferon α-2a suppositories, which were put into vagina, qod, total 9 suppositories as one therapy course, for two therapy courses. One hundred and twenty-two patients in B group were treated with thotothermal therapy. Ninty-four patients in C group were treated with interferon α-2a for two therapy courses after thotothermal therapy. The treatment outcomes were observed after three month, the relapse was observed after six month. RESULTS: The number of cuced patients in groups A,B,C were 116, 99, 82, respectively. The treatment outcomes of the three therapies showed no significant difference (P>0.05). The number of relapse patients in A, B and C groups were 10, 15 and 7, respectively. No obvious difference was demonstrated (P>0.05). The adverse reactions in A group were obviously more mild than those in the other two groups. CONCLUSION: Compared with thotothermal therapy and interferon plus thotothermal therapy, the interferon α-2a therapy in the treatment of cervical erosion has a similar effect, but with little adverse reaction and easy performation, thus, it can instead of thotothermal therapy.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2003年第7期399-401,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
干扰素Α-2A
栓剂
宫颈糜烂
疗效
不良反应
suppositories
cervix erosion
physical therapy
interferon-alpha
interferon alfa-2a
