摘要
目的研究超高频电波刀与干扰素在高危型HPV感染CIN的临床应用价值。方法选取我院在2011年1月至2013年1月间收治的82例高危型HPV感染CIN患者的临床资料,通过随机数字表法将患者分为两组,每组各41例病例。观察组接受超高频电波刀手术治疗,术后局部采用干扰素栓治疗;对照组治疗方法与观察组相同,但术后未使用干扰素。比较两组患者在治疗后3月、6月及12月时宫颈HPV感染转阴情况。结果观察组中有2例患者出现并发症,并发症率为4.9%;对照组中有8例患者出现并发症,并发症率为19.5%,观察组并发症发生率低于对照组,差异具有统计学意义(P<0.05)。观察组术后3、6、12个月的HPV转阴率均高于对照组,对比差异显著,具有统计学意义(P<0.05或P<0.01)。结论通过使用超高频电波刀手术与干扰素联合治疗,有利于促进高危型HPV感染的CIN患者创面的愈合,缩短愈合时间,同时还能控制并发症发生率,值得临床推广应用。
Objective To study the combination treatment of the loop electrosurgical excision procedure （LEEP） and interferon in patients of high-risk type HPV infection of CIN. Methods 82 cases of high-risk type HPV infection CIN patients in our hospital from January 2011 to January 2013 were divided into two groups, each group of 41 cases. After the treatment of LEEP, the observation group was treated with interferon local application while the control group was not. Results The complication rate of the observation group was 4.9% , which was significantly lower than 19.5% of the control group （ P 〈 0.05 ）. The HPV negativeness rate of observation group was higher than that of the control group （ P 〈 0. 05 or P 〈 0.01 ）. Conclusion It is beneficial to wound healing, complication control, and HPV negativeness of the LEEP and interferon cocal application for the high-risk type HPV infection of CIN, and is worthy of clinical popularization and application.
出处
《中国现代手术学杂志》
2014年第4期308-310,共3页
Chinese Journal of Modern Operative Surgery
关键词
宫颈上皮内瘤样病变
人乳头瘤病毒
干扰素Α-2A
环形电切术
cervical intraepithelial neoplasia
human papillomavirus
interferon alfa-2a
loop electrosurgical excision procedure（LEEP）
