摘要
目的 :研究非霍奇金淋巴瘤组织中PTEN和p2 7蛋白的表达作用。方法 :利用免疫组织化学技术检测77例淋巴结非霍奇金淋巴瘤 (non Hodgkin’slymphoma ,NHL)中PTEN和p2 7蛋白的表达。结果 :在NHL中 ,PTEN和p2 7蛋白的阳性率分别为 90 .9% (70 / 77)和 5 1 .9% (4 0 / 77) ;PTEN和p2 7蛋白的阳性表达强度之间呈明显正相关 (r=0 .6 84 1 ,P <0 .0 1 ) ;低度恶性组PTEN和p2 7蛋白的阳性表达强度均明显高于高度恶性组 (P <0 .0 1 ) ;B细胞性NHL中PTEN和p2 7蛋白的阳性表达强度与T细胞性NHL比较无明显差异 (P >0 .0 5 )。结论 :在NHL的进展过程中 ,PTEN蛋白表达的缺失和降低可能导致p2 7蛋白表达减少 ,使其不能有效发挥细胞周期负调控因子的抑瘤作用 。
Objective To investigate the effect of the expression of phosphatase and tensin homolog deleted on chromosome ten (PTEN)and p27 proteins in non Hodgkin's lymphoma (NHL). Methods The expressions of PTEN and p27 proteins were detected with immunohistochemical technique in 77 cases of NHL. Results In NHL, the positive rates of PTEN and p27 protein were 90.9% (70/77) and 51.9% (40/77) , respectively. The positive strength of PTEN protein was positively correlated to that of p27 protein ( r =0.6841, P <0.01). The expression intensity of PTEN and p27 proteins in the low grade group was all higher than that in the high grade group. The expression intensity of PTEN and p27 proteins in B NHL showed no significant difference with that of T NHL. Conclusion The decrease of p27 protein expression caused by the deletion and descent of PTEN protein expression cannot effectively play the anti oncogene role in negative regulation of the cell cycle, which makes the tumor cells more malignant.
出处
《湖南医科大学学报》
CSCD
北大核心
2003年第3期233-236,共4页
Bulletin of Hunan Medical University
