摘要
目的 研究 P27KiPl(Kinase inhibitor proteinl,P27)在食管良恶性病变中的表达及意义。方法 以免疫组织化学SP法检测P27在食管增生的鳞状上皮、食管息肉及食管鳞癌中的表达。结果 P27在食管增生上皮、食管息肉及食管癌中的阳性表达率分别为93.3％、100％及48.0%,三者差异有极显著性(P<0.005),良性病变阳性率显著高于恶性肿瘤(P<0.01),而且P27表达状况与食管癌淋巴转移显著相关(P<0.05)。结论 食管癌中P27表达水平显著下降,且P27低表达与淋巴结转移有关。
Objective To investigate the expression and significance of P27 in benign and malignant esophageal diseases . Methods Determination of the expression of p27 in esophageal hyperplastic squamate epithelia ( EHSE) , esophageal polyps(EP) and esophageal squamocellular cancer (ESC) was done by SP method. Results The positive rates of P27 in EHSE,EP and ESC were 93.3% ,100% and 48% respectively, and there were statisticaly significant difference between the benign and the malignant( P < 0.005) .The positive rates in benign diseases were significantly higher than that in ESC( P < 0.01) . Furthermore, the expression of P27 was colsely correlated to ESC lymph node metastasis( P < 0. 05) , but had nothing to do with differentiation. Conclusions The expression of P27 in ESC decreases significantly, and lower level of P27 correlates with lymph node metastasis.
出处
《胃肠病学和肝病学杂志》
CAS
2003年第2期179-180,共2页
Chinese Journal of Gastroenterology and Hepatology
