摘要
目的 :研究E 钙粘素 (E cadherin)基因蛋白表达与口腔疣状癌发生发展的相关性。方法 :利用免疫组织化学SP法检测 1 2例口腔疣状癌、2 0例口腔鳞癌组织中的E cadherin基因蛋白表达 ,对比分析其相关性。结果 :口腔疣状癌中的E cadherin基因蛋白阳性表达率为 83.3% ,明显高于口腔低分化鳞癌 (37.5 % ;P <0 .0 5 ) ;其阴性表达率介于高分化鳞癌与低分化鳞癌之间。结论 :E
Objective To determine the relationship between E cadherin over expression and progression in oral verrucous carcinoma.Methods Immunohistochemistry assay was performed on 12 cases of oral verrucous carcinoma (VC) and 20 cases of oral squamous epithelial cells carcinoma (SCC) using monoclonal antibody against E cadherin gene protein. Results The E cadherin positive expression in VC(83.3%) was significantly higher than that in the poorly differentiated SCC(37.5%; P <0.05),but the negative expression of E cadherin in VC was between the well differentiated squamous cell carcinoma and the poorly differentiated squamous cell carcinoma. Conclusion E cadherin over expression plays an important role in oral verrucous carcinoma .
出处
《湖南医科大学学报》
CSCD
北大核心
2003年第3期206-208,共3页
Bulletin of Hunan Medical University
基金
湖南省自然科学基金资助课题 ( 0 1JJY2 0 93 )
