摘要
目的:评价还原型谷胱甘肽治疗帕金森病的疗效。方法:13例早期帕金森病组和6例晚期帕金森病组,每例患者给予还原型谷胱甘肽1200～1800 mg,静脉滴注,1次/日,共21d。治疗前和治疗后第1、2、3、4个月末进行UPDRS评分以观察其疗效。结果:早期帕金森病患者组精神活动、行为和精神评分在治疗后第1、2、3个月较治疗前有显著性降低。日常生活活动评分和运动检查评分第1、2、3、4个月较治疗前有显著性降低。晚期帕金森病组UPDRS评分在治疗后无明显改善。结论:还原型谷胱甘肽能够暂时改善早期帕金森病患者病情。
Aim:To study the protective effects of the reduced glutathione (GSH) on patients with Parkinson' s disease. Methods: 19 patients with Parkinson s disease were classified into tow groups: the patients with early PD and the patients with late PD. GSH was administered intravenous ? 1200-1800 mg once daily,for 21 days,in an open label fashion.Then,the drug was discontinued and a follow-up examination carried-out at 1-month interval for 4 months. The clinical disability was assessed by using UPDRS at baseline and at 1-month interval for 4 months. Results: In patients with early PD,the score of Mentation Behavior and Mood had significantly decreased for three months after GSH therapy, the score of activities of Daily living and Motor examination had significantly decreased for four months. In patients with late PD, the score of Mentation Behavior and Mood, activities of Daily Living and Motor examination had not significantly changed. Conclusion:In early PD patients,GSH had symptomatic efficacy during four month and possibly retards the progression of the disease.
出处
《中国临床神经科学》
2003年第2期195-197,共3页
Chinese Journal of Clinical Neurosciences
