4Lyon MF. Imprinting and X-chromesome inactivation [ J ]. Result Probl Cell Differ, 1999,25(8) :73-90.
5Peter WL, Rudolf J. The role of DNA methylation in cancer genetics and epigenetics[J]. Aunn Res Genet, 1996,30(9):441.
6Bender CM, Zingg JM, Jones PA. DNA methylation in bladder cancer[J]. Pharm Aceutical Res, 1998,15(2) : 175.
7Ahujia N. Aging and DNA methylation in colorectal mucosa and cancer[J]. Cancer Res, 1997,58(23) :3370-3374.
8Wheeler JM, Beck NE, Kim HC, et al. Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of Hmlh1 [ J] .Proc Natl Acad Sci USA, 1999,96(18) :10296-10301.
9Ng HH, Bird A. DNA methylation and chromatin modification[ J]. Curt Opin Genet Dev, 1999,9(2) : 158-163.
10Costello JF, Fruhwald MC. Aberrant CpG-island methylation has nonrandom and tumour-type-speeitic patterns [ J ]. Nat Genet, 2000,24(2) :132-138.
3[1]Costello JF, Plass C, Arap W et al. Cyclin dependent kinase 6 (CDK6) amplification in human glioblastomas identified using two-dimensional separation of genomic DNA [J]. Cancer Res, 1997,57(7):1250-1254.
4[2]Sambrook J, Fritsch EF, and Maniatis T. Molecular Cloning: A laboratory manual [C]. 2nd Ed. Cold Spring Harbor Lab Press: Plainvies NY, 1989.
5[3]Chio CL, Drong RL, Riley RF et al. D4 dopamine receptor-mediated signaling events determined in transfected chinese hamster ovary cells [J]. J Biol Chem, 1994,269(16):11813-11819.
6[4]Furuya KN, Thottassery JV, Schuetz EG et al. Bromocriptine transcriptionally activates the multidrug resistance gene (pgp/mdr1b) by a novel pathway [J]. J Biol Chem, 1997,272(17):11518-11525.
7[5]Kamakura S, Iwaki A, Matrumoto M et al. Cloning and characterization of the 5′-flanking region of the human dopamine D4 receptor gene. Biochem Biophys Res Commun [J], 1997,235(2):321-326.
8[6]De Bustros A, Nelkin BD, Silverman A et al. The short arm of chromosome 11 is a “hot Spot” for hypermethylation in human neoplasia [J]. Proc Nat1 Acad Sci USA, 1988,85(15):5693-5697.
9[7]Baylin SB, Herman JG, Graff JR et al. Alterations in DNA methylation: A fundamental aspect of neoplasia [J]. Adv Cancer Res, 1998,72:141-196.
10[8]Herman JG, Civin CI, Issa JP et al. Distinct patterns of inactivation of p15INK4Band p16INK4A characterize the major types of hematological maliganancies [J]. Cancer Res, 1997,57(1):837-841.
6Schouten J P, McElgunn C J, Waaijer R, et al. Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification[J]. Nucleic Acids Res, 2002, 30(12): e57.
7Eldering E, Spek C A, Aberson H L, et al. Expression profiling via novel multiplex assay allows rapid assessment ofgene regulation in defined signalling pathways[J]. Nucleic Acids Res, 2003, 31(23): e153.
8Nygren A O, Ameziane N, Duarte H M, et al Specific MLPA(MS-MLPA): simultaneous CpG methylation and copy number changes Methylation- detection of of up to 40sequences[J]. Nucleic Acids Res, 2005, 33(14): e128.
9Lai K K, Lo l F, Tong T M, et al. Detecting exon deletions and duplications of the DMD gene using Multiplex Ligation-dependent Probe Amplification(MLPA)[J]. Clin Biochem,2006, 39(4): 367-372.
