摘要
目的 研究老年原发性高血压患者血栓前状态 (PTS)分子标志物的变化及血管紧张素转换酶抑制剂 (ACEI)与血管紧张素Ⅱ受体 1(AT1)拮抗剂对原发性高血压患者血栓前状态的影响。 方法 测定 40例老年原发性高血压患者及 2 0例与原发性高血压患者年龄、性别相匹配的正常对照组血浆纤维蛋白原 (Fbg)、假性血友病因子 (vWF)、P 选择素、凝血酶原激活物抑制剂 1(PAI 1)。将 40例老年高血压病患者随机分成 2组 ,依拉普利组 2 0例 ,10～ 2 0mg每日口服 ;氯沙坦组 2 0例 ,5 0～ 10 0mg每日口服 ,治疗 8周后测Fbg、vWF、P 选择素、PAI 1。 结果 老年高血压组治疗前Fbg(P <0 0 1)、vWF(P <0 0 5 )、P 选择素 (P <0 0 5 )、PAI 1(P <0 0 5 )显著高于对照组 ,药物治疗后 2组Fbg、vWF、P 选择素、PAI 1均较用药前降低 ,差异有显著性 (P均 <0 0 5 ) ,而 2组间血栓前状态指标降低无显著性差异。 结论 老年高血压患者存在血栓前状态 。
Objective To investigate the changes of the haemostatic markers in elderly hypertensive patients,and effects of angiotensin converting enzyme inhibitor(ACEI) and angiotensin Ⅱ type 1 receptor(AT1) antagonist on prothrombotic state. Methods Fbg,vWF,P-selectin,PAI-1 were detected in 40 elderly hypertensive patients and 20 sex and age-matched healthy controls.40 untreated elderly hypertensive patients were divided into two groups randomly.20 patients were treated with enalapril(10～20 mg·d -1 ) and 20 with losartan(50～100 mg·d -1 )for 8 weeks.After treatment,Fbg,vWF,P-selectin and PAI-1 were detected again. Results Haemostatic markers (Fbg,vWF,P-selectin,PAI-1)were significantly higher in elderly hypertensive patients compared with controls.Following 8 weeks treatment with enalapril or losartan,there was significant reduction in blood presure and levels of Fbg,vWF,P-selectin,PAI-1. Conclusions Prothrombotic state is present in elderly hypertensive patients and significantly altered by antihypertensive treatment with enalapril or losartan.There is no statistically significant difference between these two drugs.
出处
《实用老年医学》
CAS
2003年第3期129-131,共3页
Practical Geriatrics
