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垂体疾病经蝶术后低钠血症相关因素的分析 被引量:8

Hyponatremia after transsphenoidal surgery of pituitary diseases
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摘要 目的 探讨垂体疾病经蝶术后低钠血症的相关因素和治疗。方法 回顾 183例垂体腺瘤、15例垂体增生、18例垂体拉克囊肿和 7例垂体脓肿经蝶手术患者的临床资料。结果 在 2 2 3例中 ,4 2 .2 %术后出现低钠血症 ,其中 5 8.5 %出现于术后 4~ 7d。低钠血症与垂体疾病类型、年龄、肿瘤大小有关 ,与性别无关。 95 .7%给予补钠和补充容量治疗 ,89.4 %在 7d内缓解。结论 垂体疾病经蝶术后低钠血症多出现于术后 1周左右 ,多见于垂体增生、垂体脓肿、垂体拉克囊肿、垂体大腺瘤和老年患者 ,治疗以补钠和补充血容量为主。 Objective To clarify the associated factors and treatment of hyponatremia after transsphenoidal surgery of pituitary diseases.Methods We retrospectively reviewed the database of 183 pituitary adenomas,15 pituitary heperplasia,18 Rathke's cyst and 7 pituitary abscess,who underwent transsphenoidal surgery in our department.Results 42.2% had post operative hyponatremia.Amog them,58.5% appeared 4 to 7 days postoperatively.Hyponatremia was related to different pituitary diseases,age and tumor size,but not related to sex.95.7% was treated with salt and fluid replacement.89.4% was remitted within 7 days.Conclusions Hyponatremia often appeared about 7 days after transsphenoidal surgery of pituitary diseases,especially in pituitary hyperplasia,Rathke's cyst,pituitary abscess,pituitary macroadenomas and old patients.The principle of treatment was salt and fluid replacement.
出处 《北京医学》 CAS 北大核心 2003年第3期158-160,共3页 Beijing Medical Journal
关键词 垂体疾病 经蝶手术 低钠血症 补钠治疗 Hyponatremia Pituitary disease Transsphenoidal surgery
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参考文献5

  • 1Filippella M, Cappabianca P, Cavallo LM, et al. Very delayed hyponatremia after surgery and radiotherapy for a pituitary macroadenoma. J Endocrino[ Invest, 2002,25 : 163 - 168.
  • 2Taylor SL, Tyrrell JB, Wilson CB. Delayed onset of hyponatremia after transsphenoidal surgery for pituitary adenomas. Neurosurgery, 1995,37:649-653.
  • 3Olson BR, Gumowski J, Rubino D, et al. Pathophysiology of hyponatremia after transsphenoidal pituitary surgery. J Neurosurg, 1997,87:499- 507.
  • 4Olin BR, Rubino D, Gumowski J, et al. Isolated hyponatremia after transsphenoidal pituitary surgery. J Clin Endocrinol Metab ( United States), 1995,80:85- 91.
  • 5Peon WS, Lolin YI, Yeung TF, et al. Water and sodium disorders following surgical excision of pituitary region tumors. Acta Neurochir(Wien), 1996,138 : 921 - 927.

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