摘要
目的评估垂体腺瘤术后低钠血症发生的相关因素及预后。方法回顾性分析2008年1月至2010年12月期间收治的120例垂体腺瘤手术患者的临床资料，统计分析垂体腺瘤患者术后低钠血症的发生率及其与临床病理因素的相互关系并进行对症治疗。结果120例垂体腺瘤患者术后出现低钠血症28例（23．3％），经治疗7例患者血钠浓度在3d内恢复正常，21例在4—7d恢复正常。低钠血症与患者年龄、肿瘤大小、类型、术后早期有无尿崩症有相关性（χ2=12．6、12．4、5．38、6．51，P均〈0．05）；低钠血症与性别无关（P〉0．05）。结论垂体腺瘤术后低钠血症多见于垂体巨大腺瘤、年龄≥50岁及曾患尿崩症者，术后1—2周检测血电解质及补钠治疗有助于进一步干预和防止潜在严重并发症发生。
Objective To investigate the factors associated with hyponatremia after pituitary adenoma surgery and its prognosis. Methods Clinical data of 120 pituitary adenoma patients treated in our hospital form Jan. 2008 to Dec. 2010 were retrospectively collected. The incidence of hyponatremia after surgery, clinicopathology and related treatment were analyzed. Results In the 120 patients, 28 （23.3%） occurred hyponatremia. The blood natrium concentration recovered to normal in 7 patients within 3 days, and in 21 patients within 4 - 7 days. Hyponatremia was associated with age, size of adenoma, type and diabetes insipidus early after surgery（χ2 = 12. 6, 12. 4,5.38 and 6. 51, Ps 〈 0. 05 ）. Conclusion Hyponatremia after pituitary adenoma surgery is frequent in patients with giant pituitary adenoma, history of diabetes insipidus and older than 50 yrs. Monitoring blood electrolyte and treatment with sodium in 1 - 2 weeks after surgery would be helpful to prevent potential severe compilations.
出处
《中国综合临床》
2011年第10期1034-1036,共3页
Clinical Medicine of China
