摘要
目的 探讨重型肝炎患者人工肝支持系统 (ALSS)治疗前后外周血中肿瘤坏死因子 α(TNF α)、白细胞介素 2 (IL 2 )、白细胞介素 10 (IL 10 )、白细胞介素 15 (IL 15 )水平的变化。方法 应用血浆置换技术治疗重型肝炎患者 5 9例 ,采用ELISA法于每次治疗前后检测TNF α、IL 2、IL 10、IL 15水平 ,并观察其动态变化。结果 重型肝炎患者血清TNF α水平明显高于对照组 ,IL 2水平明显低于对照组 ,ALSS治疗后TNF α水平明显下降 ,而IL 2、IL 10则呈上升趋势 ,治疗前后IL 15水平无明显变化。结论 ALSS治疗能降低重型肝炎患者TNF α含量 ,并升高IL 2和IL 10水平 ,从而抑制炎性介质的产生 ,减轻免疫反应对肝细胞的损伤 。
Objective To study the effect of artificial liver support system(ALSS)on the concentrations of TNF-α,IL-2,IL-10 and IL-15 in patients with severe hepatitis.Methods Fifty-nine patients suffering from severe hepatitis were treated with plasmapheresis.The concentrations of TNF-α,IL-2,IL-10,IL-15 and liver function were detected before and after therapy.Results The liver function was significantly improved after plasmapheresis.The concentration of TNF-α decreased significantly,and the concentrations of IL-10 and IL-2 increased.Conclusions The ALSS treatment can effectively remove the TNF-α and increase the concentrations of IL-10 and IL-2 in the circulation,and it is valuable to improve the survival rate.
出处
《临床内科杂志》
CAS
北大核心
2003年第6期303-305,共3页
Journal of Clinical Internal Medicine
