摘要
目的探讨重型肝炎患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和HBVDNA的水平变化及其在重型肝炎发生发展中的作用。方法采用ELISA方法检测87例重型肝炎患者IL-6、IL-8和TNF-α及用PCR法检测HBVDNA水平。结果重型肝炎患者TNF-α、IL-6和IL-8的水平明显增高,与对照组比较有显著性差异(P<0.01);重型肝炎患者HBVDNA(-)组与HBVDNA(+)组的TNF-α、IL-6和IL-8水平比较,有显著性差异(P<0.05)。结论重型肝炎患者存在机体免疫功能紊乱,免疫异常的部份原因是由于细胞因子的作用,细胞因子水平的高低反映了肝细胞损伤的程度,其水平与重型肝炎患者HBV的活跃程度相关。
Objeαive To investigate the changes of TNF-α, IL-6, IL-8 and HBV-DNA levels in the sera and their role in development of severe hepatitis. Methods The levels of TNF-α, IL-6, IL-8 in 87 patients with severe hepatitis B were deteαed by ELISA. Results The levels of TNF-α, IL-6, IL-8 in patients with severe hepatitis were higher than those in healthy control （P 〈 0.01 ）. The levels in the moderate, severe chronic hepatitis B were significant difference between patients with positive HBV-DNA and negative HBV-DNA （P 〈 0.05）. Conclusions The patients with severe hepatic disease have unbalance on the regulation and control of immune funαion partly resulting from abnormal cytokines. The above cytokine levels are associated with liver damage degree and HBV-DNA replication.
出处
《临床内科杂志》
CAS
2006年第5期320-322,共3页
Journal of Clinical Internal Medicine
