摘要
目的 探讨转移抑制基因nm23-H_1在宫颈癌组织中的表达及其临床意义。方法 采用免疫组织化学法(SP法)检测nm23-H_1在41例宫颈癌组织、17例宫颈上皮内瘤样病变(CIN)组织及10例正常宫颈组织中的表达,分析其与临床病理特征的关系及与预后的关系。结果 nm23-H_1在官颈癌组织中的阳性表达率(29.3％)明显低于在正常宫颈组织中的阳性表达率(70.0％)及CIN宫颈组织中的阳性表达率(58.8％)(P<0.05);nm23-H_1的阳性表达率与宫颈癌的中位生存期有关。结论 nm23-H_1的阳性表达率降低与宫颈癌的发生有关,提示预后不良。
Objective To investigate the relationship between the expression of nm23-H_1 gene and clinical pathological factors in cervical cancer and the clinical significance. Methods Immunohsitochemical S-P method was used to determine the expression of nm23-H_1 gene in 41 cervical cancer tissues and 17 CIN cervical tissues and 10 normal ones. The relationship between the expression and clinical pathology was analyzed. Results The positive rate of nm23-H_1 gene in cervical cancer (29.39%) was significantly lower than that in CIN (58.8%, P<0.05) and normal cervical tissues (70.0%) (P<0.05). The expression of nm23-H_1 gene was correlated to postoperative survival period (P<0.05). Conclusion The decreased positive rate of nm23-H_1 gene is closely related to the onset of cervical cancer and predicts a poor prognsis.
出处
《华中医学杂志》
2003年第3期123-124,共2页
Central China Medical Journal
关键词
宫颈癌
NM23-H1基因
表达
转移
预后
Cervical cancer nm23-H_1 gene Expression of gene Metastasis Prognosis
