摘要
目的 观察凋亡基因 Caspase- 3在脉络膜黑色素瘤 (choroidal melanom a)中的表达及分型与细胞凋亡的关系。方法 收集 2 0例脉络膜黑色素瘤标本 ,对其进行 Caspase- 3免疫组织化学染色 ,观察表达情况及染色强度。结果 Caspase- 3在脉络膜黑色素瘤有较好的表达 ,在梭形细胞型中 5例 /6例呈阳性表达 ,在混合型中 6例 /8例呈阳性表达 ,在上皮样瘤细胞型中 3例 /4例呈阳性表达 ,在坏死型中 1例 /2例呈阳性表达 ,且在各型之间没有显著性差异 (P >0 .0 5 )。结论 凋亡在脉络膜黑色素瘤中存在 ;Caspase-
Objective To analyse the expression of Caspase-3 in choroidal melanoma after depigmention and the relation between different typing and apoptosis.Method We studied the expression of Caspase-3 in 20 cases of choroidal melanoma.The presence of the corresponding protiens was determined by immunohistochemistry.Results The expression of Caspase-3 was positive in choroidal melanoma,including 5 of 6 spindle cell typing,6 of 8 mixed cell typing,3 of 4 epithelioid cell tumors typing and 1 of 2 necrosis typing and no statistic significant in the different typing (P>0.05).Conclusion From these results,we can draw a conclusion:Apoptotic cell death is prevalent in choroidal melanoma Caspase-3 may be play an important role in oncogenesis and progression of choroidal melanoma.
出处
《临床眼科杂志》
2003年第3期216-218,共3页
Journal of Clinical Ophthalmology
