摘要
目的 :在小鼠实体瘤模型中研究贫血对化疗疗效的影响。方法 :用单次剂量的卡铂 (5 0mg/kg)静推造成Hb较长时间的降低。在另一组中 ,用卡铂前 7天始予rHuEPO(1 0 0 0IU/kg)皮下注射 3次 /周预防贫血的发展。两组均于卡铂用后的第 4天自小鼠的右侧腋部皮下植入肿瘤 (S1 80 小鼠肉瘤 )。植入肿瘤后的第 5天用单次剂量的CTX(6 0mg/kg)静脉注射。结果 :rHuEPO可以防治化疗所致的贫血。化疗后可见到肿瘤生长受到抑制 ,随后肿瘤又再生长。贫血组的肿瘤生长延缓时间要短于非贫血组 (6 3天比 9 3天 ) ,被纠正的贫血组的肿瘤生长延迟时间与对照组大致相仿 (9 3天 )。结论 :贫血可导致肿瘤化疗疗效的降低 ,其机制可能与肿瘤组织的低氧供有关。
Objective:To examine the impact of anemia on the efficacy of chemotherapy in solid experimental tumors.Methods:Anemia was induced using a single dose of carboplatin (50mg/kg,iv) resulting in a long lasting reduction of the hemoglobin concentration. In a second group, the development of anemia was prevented by rHuEPO( 1 000 U/kg) administered s.c three times/week starting 7 days before carboplatin application. Four days after carboplatin treatment, tumors (S 180 sarcoma of the mice) were implanted s.c under the right axilla. Tumors were treated with a dose of cyclophosphamide (60 mg/kg,iv) 5 days after implantation.Results:Chemotherapy induced anemia can be prevented by rHuEPO. A growth delay with a subsequent regrowth of the tumors was observed after chemotherapy. The growth delay in anemia group was significantly shorter compared with non anemic controls (6 3 days versus 9 3 days). In the group where anemia was prevented by rHuEPO treatment, growth delay was comparable with that of non anemia controls (9 3 days).Conclusion:Anemia reduces efficacy of chemotherapy in tumors, probably as a result of a poorer oxygen supply to tumor tissues, whereas correction of anemia by r HuEPO treatment may increase the efficacy of chemotherapy.
出处
《临床肿瘤学杂志》
CAS
2003年第3期200-203,共4页
Chinese Clinical Oncology
